养心氏片对不稳定型心绞痛患者临床疗效及血清同型半胱氨酸的影响

Therapeutic Effect of Yangxin Tablet on Patients with Unstable Angina and on Serum Homocysteine

目的:观察养心氏片治疗不稳定型心绞痛(UA)的临床疗效及对血脂水平、血清同型半胱氨酸(Hcy)水平的影响。方法:选取2013年9月至2015年12月江苏省第二中医院门诊或住院的UA患者且中医辨证为气虚痰瘀型60例随机为治疗组和对照组各30例,对照组采用常规治疗,治疗组在常规治疗基础上加用养心氏片,疗程为28 d。观察2组临床疗效、治疗前后血脂及Hcy水平的变化。结果:治疗组临床疗效和心电图改善程度均高于对照组(P<0.05)。治疗后2组血清同型半胱氨酸(Hcy)水平以及血脂水平均显著改善(P<0.05或P<0.01),且治疗组改善程度优于对照组(P<0.05)。结论:养心氏片治疗UA疗效可靠,具有一定的改善心肌缺血状态、调节血脂、保护血管内皮及稳定粥样斑块的作用。

Objective：To observe the efficacy of Yangxin Tablets on patients with unstable angina and its influence on serum lipids and homocysteine levels .Methods：The patients were randomly divided into a control group and a treatment group , with 30 cases in each .The control group were given routine treatment of western medicine , while patients in the treatment group with 30 cases were treated with routine therapy combined with Yangxin Tablets .Two groups were treated for 28 days.Clinical efficacy of two groups , levels of serum lipid and Hcy were observed .Results：After treatment, clinical and electrocardiographic effects in treatment group were higher than those of the control group （P〈0.05）.Serum lipids and Hcy of two groups were improved （P〈0.05 orP〈0.01）, while improvement of the treatment group were better than that of the control group （P〈0.05）.Conclusion：Yangxin Tab-let has a reliable clinical therapeutic effect on unstable angina , which improved myocardial blood supply , regulated blood lipids , developed blood vessel endothelial function and stabilized vulnerable atherosclerotic plaque .