瓜蒌皮注射液对风痰阻络型脑卒中的临床疗效研究

Study on Clinical Effect of Snakegourd Fruit Injection of Wind-phlegm Obstructing Collateral Type Stroke

目的:观察瓜蒌皮注射液对风痰阻络型脑卒中的临床疗效并分析其机制。方法:随机选取2014年1月至2016年1月于南京军区福州总医院第一附属医院就诊的脑卒中风痰阻络型患者70例,其中女21例,男49例;将所选患者随机分为治疗组和对照组,每组35例,2组患者均进行常规内科基础治疗,对照组在基础治疗上加以依达拉奉治疗;治疗组加以瓜蒌皮注射液治疗。2组患者均治疗4周,并在治疗前后对日常生活活动能力(ADL)、临床神经功能缺损程度评分标准(CSS)进行评价,并检测患者血浆内皮素-1(Endothelin-1,ET-1)、同时进行疗效及相关性分析。结果:在经过4周的治疗后,治疗组的有效率明显高于对照组(P<0.05),2组患者的ET-1、ADL、CSS评分均较治疗前有明显的改善(P<0.05),但除ADL评分外,治疗组的ET-1、CSS评分改善程度与对照组相比较无明显差异(P>0.05)。结论:瓜蒌皮注射液对改善风痰阻络型脑卒中患者的临床症状安全有效。

Objective：To observe the clinical curative effect of Snakegourd Fruit Injection on wind-phlegm obstructing collateral type stroke and its mechanism analysis.Methods：A total of 70 cases of patients of inpatients and outpatients in our hospital with stroke phlegm type were randomly selected,including 21 cases of female,49 male;And they s were randomly divided to treatment group （35 cases）,control group （35 cases）,two groups of patients were given conventional medical therapy and control group was also given edaravone treatment;and treatment group Snakegourd Fruit injection treatment.Patients in the two groups were treated for 4 weeks,and then evaluate the activities of daily living （ADL）,clinical neural function defect score standard （CSS）before and after treatment,plasma endothelin in patients with endothelin-1 （ET-1）,at the same time and correlation analysis.Results：After 4 weeks＇treatment,the treatment group＇s effective rate was significantly higher than that of the control group （P 〈0.05）, compared with before treatment,patients＇ET-1,ADL,CSS scores in the two groups improved significantly （P 〈0.05）,But apart from the ADL score,the treatment group＇s ET-1,CSS score had no significant improvement compared with the control group （P 〉0.05）.Conclusion：Snakegourd Fruit Injection can improve the wind-phlegm obstructing collateral type stroke patients with safe and effective clinical outcome.