摘要
目的:评价养心氏片治疗冠心病合并糖尿病的临床疗效。方法:将100例冠心病合并糖尿病的患者随机分为对照组(西药治疗)和养心氏组(西药治疗+养心氏片),每组各50例,疗程为6个月。观察比较2组患者的心绞痛症状、血糖、Hb A1c、hs-CRP、NT-pro BNP、Hcy和不良反应。结果:治疗后,1)养心氏组心绞痛症状改善总有效率为92.00%,高于对照组的82.00%,差异有统计学意义(P<0.05);2)养心氏组空腹血糖、餐后2 h血糖和Hb A1c分别为(5.3±1.1)mmol/L、(9.2±1.8)mmol/L和(5.6±0.5)%,低于对照组的(6.1±1.5)mmol/L、(10.4±2.1)mmol/L和(6.1±0.8)%,P<0.05;3)养心氏组hs-CRP为(1.21±0.22)mg/L,低于对照组的(1.53±0.43)mg/L,P<0.05;4)养心氏组NT-pro BNP为(667±145)ng/L,低于对照组的(927±136)ng/L,P<0.05;5)养心氏组Hcy为(8.64±0.47)μmol/L,高于对照组的(9.88±0.39)μmol/L,P<0.05;6)养心氏组不良反应发生率为2.00%,低于对照组的18.00%,P<0.05。结论:养心氏片联合西药治疗冠心病合并糖尿病比常规西药治疗效果更佳。
Objective:To evaluate the effects of YangXinShi tablet oncoronary heart disease complicated with diabetes.Methods:A total of 100 patients who were diagnosed as coronary heart disease complicated with diabetes in the hospital were collected.All patients were randomly divided into YangXinShi group and control group,50 cases in each group.The control group on the western medicine(western medicine treatment)treatment basis and the YangXinShi group given oral administration of YangXinShi tableton the basis of the treatment in the control.After 6 months treatment,the clinical symptoms of angina pectoris,blood glucose,HbA1c, LVEF,hs-CRP,NT-proBNP,Hcy and adverse reactions of all patients were detected.Results:After treatment,1)the total effective rate of improving angina pectoris in YangXinShi group(92.00%)was significantly higher than that of in control group(82.00%) and the difference was statistically significant(P 〈0.05);2)the fasting plasma glucose,two hourspostprandial glucose and HbA1c in YangXinShi group(5.3 ±1.1)mmol/L、(9.2 ±1.8)mmol/L and(5.6 ±0.5)% were significantly lower than that of in control group (6.1 ±1.5)mmol/L、(10.4 ±2.1)mmol/L and(6.1 ±0.8)%,P 〈0.05;3)the hs-CRP in YangXinShi group (1.21 ± 0.22)mg/L was significantly lower than that of in control group (1.53 ±0.43)mg/L,P 〈0.05;4)the NT-proBNP in YangXinShi group (667 ±145)ng/L was significantly lower than that of in control group (927 ±136)ng/L,P 〈0.05;5)the Hcy in YangXin-Shi group (8.64 ±0.47)μmol/L was significantly lower than that of in control group (9.88 ±0.39)μmol/L,P 〈0.05;6)the in-cidence of adverse reactions in YangXinShi group(2.00%)was significantly lower than that of in control group(18.00%),P 〈0.05.Conclusion:YangXinShi tablet combined with western medicineon coronary heart disease complicated with diabetes was better than the conventional western medicine treatment.
出处
《世界中医药》
CAS
2016年第12期2707-2710,共4页
World Chinese Medicine
关键词
养心氏片
冠心病
糖尿病
心绞痛
糖化血红蛋白
YangXinShi tablet
Coronary heart disease
Diabetes
Angina pectoris
HbA1c