中药肉桂的化学成分研究

Chemical Constituents in Cassia Bark

目的：对中药肉桂（Cinmamomum cassia Presl）的化学成分进行研究。方法：采用正、反相硅胶柱色谱、凝胶柱色谱及半制备液相色谱等方法进行分离纯化,利用波谱解析结合理化性质鉴定化合物结构。结果：分别鉴定为1）：（-）开环异落叶松脂醇,2）：（-）异落叶松脂素,3）：Erythro-1-C-syringylglycerol,4）：2-甲基-3,5-羟基色酮,5）：浙贝素,6）：松柏醛,7）：肉桂酸。结论：其中1-3为首次从该植物中分离得到,化合物4-5为首次从该属植物中分离得到。

Objective：To study the chemical constituents in Cassia Bark.Methods：Silica gel,ODS,Sephadex LH-20 column chromatography and semi-preparative HPLC were used to isolate and purify the compounds of Cassia Bark.The structures of the compounds were identified on the basis of their physicochemical properties,spectroscopic data,and with the literature.Results：Seven compounds were isolated from the Cassia Bark including （-）-secoisolariciresinol （1）,（-）-isolariciresinol （2）,Erythro-1-C-syringylglycerol （3）,（-）-gynuraone （4）,zhebeiresinol （5）,coniferyl aldehyde （6）,cinnamic acid （7）.Conclusion：Compounds 1 -3 were isolated from Cassia Bark for the first time.Compounds 4 -5 were obtained from this genus plants for the first time.