摘要
目的探讨清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症疗效及对炎性细胞因子、SOD、MDA水平的影响。方法将100例肝胆湿热型急性肝内胆汁淤积症患者随机分为2组,对照组60例给予西药治疗,观察组60例在此基础上加用清热化瘀中药治疗,观察2组治疗前后中医证候积分、肝脏功能指标、炎症细胞因子、SOD及MDA水平变化情况,统计2组近期疗效和不良反应发生情况。结果治疗后2组目俱黄、胁肋疼痛、脘闷腹胀、烦热、口干而苦、小便黄赤积分及肝脏功能指标、炎症细胞因子水平均显著低于治疗前(P均<0.05),且观察组各项指标水平均显著低于对照组(P均<0.05);2组SOD和MDA水平均显著优于治疗前(P均<0.05),且观察组各项指标水平均显著优于对照组(P均<0.05);观察组近期治疗总有效率显著高于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论清热化瘀中药治疗肝胆湿热型急性肝内胆汁淤积症可有效缓解全身症状体征,改善肝脏功能,调节炎性细胞因子及SOD、MDA水平,且未增加不良反应发生风险。
Objective It is to investigate the effect of traditional Chinese medicine of clearing-heat removing blood-stasis on the treatment of acute intrahepatie cholestasis of liver and gallbladder damp heat syndrome and its influence on the levels of inflammatory eytokines, SOD and MDA. Methods 100 patients with acute intrahepatic eholestasis of liver and gallbladder damp heat syndrome were randomly divided into 2 groups with 60 cases in each, the patients were treated with western medi- cine in the control group, and with traditional Chinese medicine of clearing-heat removing blood-stasis on the basis of the treat- ment of the control group in the observation group. The changes of TCM syndrome score, the levels of liver function indexes, inflammatory cytokines, SOD and MDA before and after treatment were observed, the short-term effect and adverse reactions of the two groups were analyzed. Results After treatment, the scores of eye yellow, hypochondriac pain, abdominal distension nausea, hot upset, dry and bitter taste in mouth, yellow urination, and liver function index, inflammatory cytokine levels in the two groups were significantly decreased than those before treatment ( all P 〈 0.05 ) , and those of the observation group were significantly lower than the control group ( all P 〈 0.05 ) ; the levels of SOD and MDA in the two groups were significantly better than those before treatment ( all P 〈 0.05) , and those of the observation group were significantly better than the control group ( P 〈 0.05 ) ; the total effective rate of the observation group was significantly higher than the control group ( P 〈 0.05 ) ; there was no significant difference in the incidence of adverse reactions between the two groups ( P 〉 0.05 ). Conclusion The traditional Chinese medicine of clearing-heat removing blood-stasis can effectively relieve the symptoms and signs in the treat- ment of acute intrahepatie cholestasis of liver and gallbladder damp heat syndrome, improve liver function, regulated the levels of inflammatory cytokines and SOD and MDA, and do not increase the risk of adverse reactions.
作者
李恒飞
杨帆
陆定波
LI Hengfei YANG Fan LU Dingbo(Hubei Provincial Hospital of TCM, Wuhan 430074, Hubei, Chin)
出处
《现代中西医结合杂志》
CAS
2017年第12期1272-1275,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
清热化瘀中药
急性肝内胆汁淤积症
肝胆湿热
traditional Chinese medicine of clearing-heat removing blood-stasis
acute intrahepatic cholestasis
liver andgallbladder damp heat syndrome