自拟红藤饮辅助治疗重症腹腔感染疗效及对T淋巴细胞和Toll样受体的影响

Effect of Hongtengyin in adjuvant treatment of severe abdominal infection and its influence on T lymphocytes and Toll like receptors

目的探讨红藤饮辅助治疗重症腹腔感染的疗效及对血T淋巴细胞与Toll样受体的影响。方法将70例住院治疗的重症腹腔感染患者随机分为2组,对照组给予常规基础治疗,观察组在此基础上给予自拟红藤饮治疗,治疗2周后统计2组临床疗效,观察2组治疗前与治疗2周后外周血T淋巴细胞(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、Toll受体(TLR2与TLR4)水平和APACHEⅡ评分与胃肠功能评分变化情况。结果治疗2周后,观察组治愈率、显效率与总有效率均明显高于对照组(P均<0.05)。治疗后2组血清CD3^+、CD4^+、CD4^+/CD8^+均显著升高(P均<0.05),CD8^+和血清TLR2与TLR4 mRNA均显著降低(P均<0.05),且观察组各项指标改善情况明显优于对照组(P均<0.05)。治疗后2组APACHEⅡ与胃肠功能评分均显著降低(P均<0.05),且观察组治疗后APACHEⅡ与胃肠功能评分显著低于对照组(P均<0.05)。结论中药红藤饮辅助治疗重症腹腔感染临床疗效更好,可有效调节T淋巴细胞与PBNC核细胞中的TLR表达,明显改善患者生理健康与胃肠功能。

Objective It is to investigate the effect of Hongtengyin in adjuvant treatment of severe abdominal infection and effects on blood T lymphocytes and Toil like receptors. Methods 70 patients with severe abdominal infection were randomly di- vided into two groups, the patients were received routine treatment in the control group, and were treated by Hongtengyin on the basis of the control group in the observation group, after 2 weeks of treatment, the clinical curative effects of the 2 groups were analyzed, the changes of peripheral blood T lymphocytes （ CD3 ＋ , CD4＋ , CD8 ＋ , CD4 ＋/CD8 ＋ ） , Toll receptor （ TLR2 and TLR4） levels, APACHE II score and gastrointestinal function score were observed before and after treatment for 2 weeks. Results After 2 weeks of treatment, the cure rate, significantly effective rate and total effective rate in the observation group were significantly higher than those in the control group （ all P 〈 0.05 ）. After treatment, serum CD3＋ , CD4 ＋ and CD4 ＋ / CD8 ＋ were significantly increased in the two groups （ all P 〈 0.05 ） , CD8 ＋ and TLR2, TLR4 mRNA were significantly de- creased （all P 〈 0.05 ） , and all the targets in the observation group were better than those in the control group （ all P 〈 0.05）. After treatment, the scores of APACHE II and gastrointestinal function in the two groups were significantly lower （all P 〈 0.05） , and the scores in the observation group were significantly lower than those in the control group （ all P 〈 0.05 ）. Conclusion The clinical curative effect of Chinese medicine Hongtengyin in adjuvant treatment on severe abdominal infection is better, it can effectively regulate the expression of TLR in T lymphocytes and PBNC cells, and improve the physical health and gastrointestinal function of patients.