摘要
DNA损伤响应涉及到损伤的感应、信号的传递、DNA修复等一系列通路和过程。在这些过程中,有大量蛋白质以其不同的修饰状态参与其中。有些蛋白质的修饰参与信号的识别和传递;有些修饰改变酶的活性;而有些修饰则参与调节,有大量的研究者对参与DNA损伤相关蛋白的功能及修饰进行了研究。它们在DNA损伤响应分别发挥着不同的功能,其协同作用使细胞得以从细胞周期关卡中恢复,进入正常周期。有大量研究者对参与DNA损伤相关蛋白的功能及其修饰进行了研究。在本综述中我们将从DDR所涉及的信号通路角度,主要对DDR及DNA损伤修复途径中所涉及到的蛋白质及其修饰进行总结。
DNA damage response （DDR） is a complicated process, including signal sensing, signal transduc- tion, and DNA damage response, etc. During this process, lots of proteins are involved in with different kinds of post modifications. The abundance, especially modification status of those proteins play different roles and determine the life of cells encountered with DDR. There are great amount of studies around the proteins and protein modifications related with DDR, not only because of the biological significance, but also the potential of DDR in clinical application in tumor therapy. In this review, we summarized the modifications in some key proteins involved in DDR, from damage sensor to transducer and finally effecter.
作者
杜珊珊
张宇星
王全会
DU Shanshan ZHANG Yuxing WANG Quanhui(Key Laboratory of genome science and bioinformatics, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100049, China Sino-Danish College of University of Chinese Academy of Sciences, Beijing 100049, China)
出处
《生命的化学》
CAS
CSCD
2017年第1期93-103,共11页
Chemistry of Life
基金
北京市自然科学基金项目(5132023)
重庆市研究基础计划项目(cstc2013jcyj C00001)
关键词
DNA损伤响应
DNA损伤修复
蛋白质翻译后修饰
非同源末端连接
同源重组修复
DNA damage response
DNA repair
Protein post translational modification
non-homologous end joining （NHEJ）
homologous recombination repair （HR）
