不同抗生素对早期梅毒的临床疗效观察

Clinical Observation of Different Antibiotics on Early Syphilis

目的:观察不同抗生素对早期梅毒的临床疗效观察。方法:随机选取于2014年5月-2015年5月前来本科接受诊治的Ⅰ、Ⅱ期梅毒患者76例。通过随机数字法分为试验组(使用阿奇霉素治疗)和对照组(使用苄星青霉素治疗),每组各38例。观察临床皮疹消失时间;治疗前,治疗后3、6、9、12个月分别对患者进行甲苯胺红不加热血清试验(TRUST),对比两组患者不同时间点转阴率的情况及临床疗效。结果:试验组梅毒Ⅰ期梅毒皮疹症状消失时间为6 d左右,Ⅱ期梅毒为7 d左右;对照组梅毒Ⅰ期梅毒皮疹症状消失时间为6 d左右,Ⅱ期梅毒为8 d左右,两组临床皮疹症状消失时间两个时期比较,差异均无明显统计学意义(P>0.05)。两组患者治疗后转阴率随着时间的增加不断增加,试验组治疗后12个月达89.47%,对照组达86.84%,两组间转阴率比较差异无统计学意义(P>0.05)。试验组临床治愈率为84.21%,对照组临床治愈率为81.57%;试验组血清学治愈率为89.47%,对照组血清学治愈率为86.84%,两组患者的治愈率比较差异无统计学意义(P>0.05)。结论:阿奇霉素和苄星青霉素对早期梅毒的临床疗效均有效,两组间无疗效差异。

Objective： To observe the clinical effect of different antibiotics on early syphilis.Method： 76 patients with stage Ⅰ and Ⅱ syphilis treated in our hospital from May 2014 to May 2015 were randomly selected, they were divided into experimental group （ Azithromycin therapy ） and control group （ Benzylpenicillin therapy ） according to random number table, 38 cases in each group.The time of rash disappeared were observed.Before and after 3, 6, 9 and 12 months treatment, they were given plasma tolulizedred unheated serum test （ TRUST ） .The negative conversion rate of different time points and the clinical effect of two groups were compared.Result： In experimental group, the rash symptoms disappeared time in stage Ⅰ syphilis was about 6 d, in stage Ⅱ syphilis was about 7 d ; in control group, the rash symptoms disappeared time in stage Ⅰ and Ⅱ syphilis was respectively 6 d and 8 d, there were no significant differences （ P〉0.05 ） .The negative conversion rate of two group increased with time, after 12 months of treatment, the negative conversion rate of experimental group was 89.47%, the control group was 86.84%, the difference was no statistically significant （ P〉0.05 ） .The clinical cure rate of experimental group was 84.21%, control group was 81.57%; the serological cure rate of experimental group was 89.47%, control group was 86.84%, the differences were no statistically significant （P〉0.05） .Conclusion： The clinical, effect of azithromycin and penicillin on early syphilis both are effective, there is no difference between the two groups.