CD4^+CD25^+调节性T细胞与造血干细胞移植后移植物抗宿主病的相关性

CD4^+CD25^+ regulatory T cells and graft-versus-host disease after hematopoietic stem cell transplantation

背景:自身反应性T细胞是一群通过某些机制发挥外周免疫抑制效应,以确保处于机体免疫耐受状态的特殊细胞群。天然CD4^+CD25^+调节性T细胞最新表面标志物的发现使外周T细胞调节或抑制的概念重新被重视起来,一些研究小组开始探讨异基因造血干细胞移植的动物模型中调节性T细胞的作用。目的:通过对小鼠移植模型过继转移CD4^+CD25^+调节性T细胞,总结移植物抗宿主病预防的最新研究结果,同时探讨造血干细胞移植临床研究的最新发现。方法:应用计算机检索2000至2015年CNKI数据库及Pub Med/Medline数据库有关CD4^+CD25^+调节性T细胞与移植物抗宿主病相关性研究的文献。对资料进行初审,按纳入和排除标准筛选后对其中46篇相关性强的文献进行进一步分析。结果与结论:CD4^+CD25^+调节性T细胞表达的转录因子FOXP3是介导免疫调节功能、预防自身免疫性疾病发生的关键。诱导免疫耐受是异基因造血干细胞移植成功的前提,目前国内外许多实验室正在移植模型和临床试验中研究CD4^+CD25^+调节性T细胞的功能。CD4^+CD25^+调节性T细胞在造血干细胞移植后发生植物抗宿主病中起着重要作用,在有效预防和治疗移植物抗宿主病的同时还能保留移植物抗白血病效应。

BACKGROUND： Autoreactive T cells are a group of specialized cells that exert a peripheral immunosuppressive effect through certain mechanisms ensuring self-tolerance within the adaptive immune system. The discovery of the latest surface markers for natural CD4＋CD25＋ regulatory T cells has re-emphasized the concept of peripheral regulation or suppression of T cells. Several groups have begun to investigate the role of regulatory T cells in animal models of allogeneic hematopoietic stem cell transplantation.OBJECTIVE：To review the recent results regarding protection from graft-versus-host disease by adoptively transferred CD4＋CD25＋regulatory T cells in mice and to discuss the latest findings from clinical studies on hematopoietic stem cell transplantation.METHODS：We retrieved CNKI,Pub Med and Medline databases for articles concerning CD4＋CD25＋regulatory T cells and graft-versus-host disease published from 2000 to 2015.According to inclusion and exclusion criteria,46 papers were included in result analysis.RESULTS AND CONCLUSION：CD4＋CD25＋regulatory T cells expressing the transcriptional repressor FOXP3 mediate immunoregulatory functions and are critical for the prevention of autoimmune diseases.As peripheral tolerance induction is a prerequisite for successful allogeneic hematopoietic stem cell transplantation,the role of CD4＋CD25＋regulatory T cells in transplantation models and clinical trials is now under investigation in many laboratories.CD4＋CD25＋regulatory T cells play an important role in the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.CD4＋CD25＋regulatory T cells not only effectively prevent and treat graft-versus-host disease but also retain graft-versus-leukemia effect.