特发性结节样肾小球硬化的诊断与治疗进展

Progress in diagnosis and treatment for idiopathic nodular glomerulosclerosis

特发性结节样肾小球硬化(idiopathic nodular glomerulosclerosis,ING)是一种罕见的肾脏疾病,发病率低,临床表现非特异。该病病理表现与糖尿病肾病相似,以肾小球结节样硬化为特征性表现,但于非糖尿病人群中发病。确诊及鉴别诊断需要肾组织免疫病理及电镜检查。至今对其机制、病因的讨论仍存在较多争议。本文汇总国内外针对ING的相关研究文献,对该病危险因素、诊断及治疗进展进行概述及阐释。

Idiopathic nodular glomerulosclerosis （ING） is a rare kidney disease which has a low morbidity with no specific manifestations. It resembles nodular diabetic glomerulosclerosis in pathology features but occurs in nondiabetic patients. The diagnosis and differential diagnosis mainly rely on the immunofluorescence and electron microscopic （EM） findings. Unfortunately, controversies still exist on the exact mechanism and etiology of ING. This article mainly discussed the risk factors, diagnosis and treatment of ING based on the current studies worldwide.