HIF-1α在子宫内膜异位症中的研究进展

Research progress of HIF-1α in endometriosis

子宫内膜异位症(Endometriosis,EMs)是育龄妇女的常见病,但其发病机制至今仍不清楚。越来越多的证据表明,低氧与EMs发生发展有密切的联系。在EMs异位组织中低氧诱导因子-1α(HIF-1α)的表达明显增高;HIF-1α通过调节雌激素产生、血管生成、细胞增殖和炎症等相关基因,促进EMs发展;HIF-1α是EMs有氧糖酵解过程中关键的调节因子;抑制HIF-1α的表达有助于抑制EMs的发生发展,表明HIF-1α在EMs的病理形成中的作用。本文介绍HIF-1α的研究进展,着重论述其在EMs中的作用。

Endometriosis （EMs） is a common gynecologic disorder affecting 10-15% of women in reproductive age. However, the underlying etiology of the disease is still poorly understood. In recent years,a growing body of evidence validated that hypoxia developed a close relationship with EMs, and the expression of hypoxia inducible factor-lalpha （HIF-1α） was significantly increased in development of EMs. HIF-1α contributed to endometriosis by regulating the genes which were essential to estrogen production, angiogenesis,proliferation and inflammation. In addition, HIF-1α is a key regulator in the process of aerobic glycolysis in EMs. Furthermore, inhibition of the expression of HIF-1α contributed to suppress EMs progression, suggesting HIF-1α plays a critical function in EMs. This paper reviews the research progress of HIF-1α and its role in endometriosis.