脱氢表雄酮在卵巢储备功能减退患者中的应用研究进展

Research progress of dehydroepiandrosterone supplementation in patients with diminished ovarian reserve

卵巢储备功能减退(DOR)、卵巢低反应(POR)是辅助生殖技术(ART)治疗过程中的难点。近年有研究报道,对于辅助生殖技术治疗中卵巢功能减退和卵巢低反应的妇女通过各种类型雄激素包括睾酮和脱氢表雄酮(DHEA)补充的预治疗可增加获卵数,改善胚胎质量,提高妊娠率和活产率,但有部分研究持反对意见,认为添加雄激素未能改善卵巢储备功能减退患者体外受精治疗的结局。本文对近年来DHEA在DOR患者中的应用研究进展做一个综述。

Treatment of diminished ovarian reserve （DOR） and poor ovarian response （POR） is difficulty in the process of the assisted reproductive technology （ART）. In recent years, some studies reported that pretreatment of various types of androgen including testosterone and dehydroepiandrosterone （DHEA） can increase the number of retrieved oocytes, and improve embryo quality,pregnancy rate and live birth rate in ART treatment of women with DOR or POR. However, some studies have objections that administration of androgen fails to improve ovarian reserve and the clinical outcome in the patients undergone IVF treatment. Research progress of DHEA supplementation in patients with DOR is reviewed in this paper.