骨不连治疗方法的研究进展

Latest Research Progress of Treatment Bone Nonunion

美国AAOS诊断骨不连定义:是指骨折后至少9个月且连续3个月动态观察未见到骨折有明显的愈合征象,延迟愈合或者骨不连概率为5%~10%。目前临床上治疗骨不连仍以手术治疗、药物治疗、物理治疗、分子生物治疗以及中医中药治疗等为主,近年来随着对骨愈合基本过程、机制的研究及对干细胞研究的关注,认识到了骨髓间充质干细胞在骨折愈合机制中的机理,发现了一些干细胞对骨愈合的调控机制。对骨折愈合过程、机制及骨不连治疗方法选择做一综述概括,探讨骨髓间充质干细胞治疗骨不连的有效性及可能性,为该疾病的临床治疗决策提供相关理论依据。

Diagnosis of bone nonunion of AAOS is defined refers to fracture at least 9 months and 3 consecutive months of dynamic observation did not see significant signs of fracture healing, delayed union or nonunion probability of about 5% to 10%. At present, the clinical treatment of nonunion is still surgery, drug therapy, physical therapy, molecular biotherapy and traditional Chinese medicine treatment, etc .In recent years with the basic process of bone healing, mechanism research and stern cell research attention to the mesenchymal stem cells in the mechanism of fracture healing mechanism, found some stern cells on the regulation of bone healing mechanism. The mechanism and mechanism of bone nonunion treatment were summarized, and the effectiveness and possibility of stem cell therapy for nonunion of bone were discussed, which could provide a theoretical basis for the clinical treatment of this disease.