血小板生成素联合激素治疗免疫性血小板减少性紫癜

Thrombopoietin Combined With Hormone in the Treatment of Immunologic Thrombocytopenic Purpura

目的探讨血小板生成素与激素联合治疗免疫性血小板减少性紫癜(ITP)的临床效果。方法选取我院2013年4月—2016年3月收治的ITP患者74例为研究对象,经随机数字表法分为观察组与对照组,每组37例,对照组给予糖皮质激素治疗,观察组在对照组基础上联合血小板生成素治疗,观察两组患者治疗效果及血小板计数、凝血功能变化。结果观察组治疗总有效率为94.59%,同对照组的78.38%对比,差异有统计学意义(P<0.05);治疗前两组患者血小板计数及凝血功能差异无统计学意义(P>0.05),治疗后均有改善,观察组治疗后血小板计数高于对照组,凝血酶原时间较对照组短,差异有统计学意义(P<0.05)。结论血小板生成素联合激素治疗ITP,疗效确切,能有效提高患者血小板计数,改善凝血功能。

Objective To investigate the clinical effect of thrombopoietin combined with hormone in the treatment of immune thrombocytopenic purpura （ITP）. Methods 74 patients with ITP treated in our hospital from April 2013 to March 2016 were selected as the research objects and randomly divided into the observation group and the control group with 37 cases in each group. Patients in the control group were given glucocorticoid therapy while patients in the observation group were given thrombopoietin treatment based on the treatment in the control group. The therapeutic effect, platelet count and coagulation function of two groups were observed. Results The total effective rate of observation group was 94.59%, which was significantly higher, compared to 78.38% in the control group, and the difference was statistically significant （P 〈 0.05）. There was no significant difference in platelet count and coagulation function between the two groups before treatment （P 〉 0.05）, but the effect was improved after the treatment. After treatment, the platelet count of the observation group was significantly higher than that of the control group and prothrombin time was significantly shorter than that in the control group. The difference was statistically significant （P 〈 0.05）. Conclusion The effect of thrombopoietin combined with hormone therapy in the treatment of patients with ITP is effective. This method can effectively improve the patients＇ platelet count and blood coagulation function.