培美曲塞联合顺铂治疗非小细胞肺癌的临床疗效评价

Clinical Evaluation of Pemetrexed Combined With Cisplatin in the Treatment of Non Small Cell Lung Cancer

目的探讨培美曲塞联合顺铂药物对非小细胞肺癌治疗的效果。方法选取我院2015年3月—2016年3月收治的非小细胞肺癌患者共48例,所有患者在用药前7 d行维生素B_(12)以及叶酸治疗,用药前1 d、用药当日以及用药后1 d口服地塞米松,培美曲塞500 mg/m^2,10 min静脉注射,采用顺铂治疗,75 mg/m^2,每21 d为1个周期。持续用药42 d后对患者的治疗效果进行比较研究。结果在48例患者中,常出现的临床不良反应为骨髓抑制以及局部静脉炎,部分患者病情有所改善。结论将培美曲塞联合顺铂药物应用于非小细胞肺癌治疗中,具有极为显著的临床效果,这对于临床研究具有重要作用。

Objective To investigate the effect of pemetrexed combined with cisplatin in the treatment of non-small cell lung cancer. Methods 48 cases of non-small cell lung cancer patients were selected in our hospital from March 2015 to March 2016, all patients in the treatment before 7 d of vitamin Bl2 and folic acid treatment, medication, medication before 1 d and 1 d after administration of oral dexamethasone, pemetrexed 500 mg/m^2, 10 min intravenous injection with cisplatin in the treatment of 75 mg/m^2. Every 21 d for 1 cycles. Comparative study on the therapeutic effect of 42 d after continuous administration. Results In 48 patients, the clinical adverse reactions were bone marrow suppression and local phlebitis. Conclusion Pemetrexed combined with cisplatin in the treatment of non-small cell lung cancer, has a very significant clinical effect, which has an important role in clinical research.