妊娠糖尿病患者血清Hcy、ADPN和CRP水平变化及意义

Changes and Significance of Level of Hcy,ADPN and CRP in Serum in Patients With Gestational Diabetes Mellitus

目的探讨妊娠糖尿病患者血清中同型半胱氨酸(Hcy)、脂联素(ADPN)和C反应蛋白(CRP)水平变化及对妊娠糖尿病诊断的意义。方法选取178例妊娠妇女作为研究对象,将其分为妊娠糖尿病组(GDM组)66例和健康妊娠组(对照组)112例,检测所有受试孕妇血清中Hcy、ADPN和CRP水平,并分析GDM患者三项指标的相关性。结果 GDM组血清血糖、Hcy、CRP水平高于对照组(P<0.05);GDM组ADPN水平低于对照组(P<0.05);血清Hcy、CRP和ADPN水平可能是影响GDM的独立危险因素(P<0.05)。结论 GDM患者机体处于炎症反应状态,检测妊娠妇女血清中Hcy、CRP和ADPN水平有助于GDM的诊治。

Objective To investigate the changes of homocysteine （Hcy）, adiponeetin （ADPN） and C reactive protein （CRP） levels in serum of patients with gestational diabetes mellitus （GDM） and their significance in the diagnosis of gestational diabetes mellitus （GDM）. Methods 178 cases of pregnant women were selected, and were divided into gestational diabetes mellitus group （GDM group, 66 cases） and healthy pregnancy group （control group, 112 cases）. Using automatic biochemical analyzer to detected Hcy, ADPN and CRP levels in serum of pregnant women, and analyze the correlation between three indexes of GDM patients. Results The serum glucose, Hey and CRP levels in the GDM group were significantly higher than those in the control group （P〈0.05）, and the ADPN level in the GDM group was significantly lower than that in the control group （P〈0.05）. Serum levels of Hcy, CRP and ADPN may be independent risk factors for GDM （P〈0.05）. Conclusion The body of GDM patients is in the state of inflammation, and the detection of Hcy, CRP and ADPN in serum of pregnant women is helpful to the diagnosis and treatment of GDM.