康复综合治疗对阿尔茨海默病(AD)患者脑电特征的影响分析

Effect of Comprehensive Rehabilitation Therapy on Electroencephalogram(EEG) in Patients With Alzheimer's Disease(AD)

目的分析康复综合治疗对阿尔茨海默病(AD)患者脑电特征的影响。方法选择我院自2015年8月—2016年7月收治的AD患者50例作为研究对象,依据不同治疗方法,将其均分两组,予以常规治疗的患者作为参照组,予以康复治疗的患者作为实验组,对两组患者的治疗效果进行分析和总结。结果两组患者经不同方法治疗后,实验组患者的MMSE评分(18.99±1.67)和BI评分(47.36±4.62),均优于参照组(15.04±1.23)、(40.41±4.37),差异具有统计学意义(t_1=9.522 3,t_2=5.464 4,P<0.05)。实验组患者的脑电高频带相对功率β_1、β_2(1.255±0.223)、(1.034±0.257)比值参数也相对较优,组间数据对比,差异具有统计学意义(t_3=5.504 6、t_4=7.160 7,P<0.05)。结论 AD患者予以康复治疗可以使认知功能和日常生活活动功能有效改善,可以将该治疗方法在临床上进一步实践。与此同时,脑电特征可以对康复效果进行评价。

Objective To analyze the effect of comprehensive rehabilitation therapy on EEG characteristics in patients with Alzheimer＇s disease （AD）. Methods 50 eases of patients with AD admitted in our hospital from August 2015 to July 2016 were divided into two groups according to the treatment group. The patients treated with conventional therapy were treated as reference group, Patients were treated as rehabilitation group, and finally the treatment effect of the two groups of patients were analyzed and summarized. Results The MMSE scores （1 8.99 ± 1.67） and BI scores （47.36 ± 4.62） in the experimental group were significantly higher than those in the control group （15.04 ± 1.23） and （40.41 ± 4.37） after treatment with different methods. The difference was statistically significant （t1=9.522 3, t2：5.464 4, P 〈 0.05）. Patients in the experimental group the EEG frequency band relative power of β1,β2 （1.255 ± 0.223）, （1.034 ± 0.257） ratio parameter is relatively excellent, data comparison between groups, the difference was statistically significant （t3=5.504 6, t4=7.160 7, P 〈 0.05）. Conclusion Rehabilitation therapy in patients with AD can improve the function of cognitive function and daily life activities, and the treatment can be further practiced in clinical practice. At the same time, EEG features can evaluate the efficacy of rehabilitation.