摘要
目前药物防治仍是控制流感的主要措施之一。现有的流感防治药物主要包括M2离子通道阻滞剂和神经氨酸酶抑制剂,临床上虽有一定治疗作用,但其耐药性也日益突显。近年来,随着晶体学、病毒学及其他相关学科在制药领域的深入应用,不少新药已进入临床(前)试验,并取得了良好的抗病毒效果。其中最具代表性的包括广谱抗流感病毒血凝素抗体和病毒RNA聚合酶复合物小分子抑制剂。本文以流感病毒被用于靶标进行药物设计的几种重要蛋白为主线,分别介绍了近年来出现的一些具有较好应用前景的流感防治药物,以期为流感疫情防控提供参考。
Drug control is still one of the main measures to control influenza. The current influenza prevention and treatment drugs mainly include M2 ion channel blockers and neuraminidase inhibitors. They have a certain therapeutic effect,but their resis?tance has also become increasingly prominent. In recent years,with the in-depth application of crystal lography,virology and other re?lated disciplines in the field of pharmacy,many new drugs have entered the(pre-)clinical test stage,and achieved good antiviral ef?fects. The most representatives include broad-spectrum anti-influenza virus hemagglutinin antibody and viral RNA polymerase complex small molecule inhibitors. Here,we introduce some new drugs against influenza so as to provide a reference for the prevention and con?trol of influenza epidemic.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2017年第3期220-228,共9页
Journal of International Pharmaceutical Research
基金
国家重点研发计划(2016YFC1200905)
国家高技术研究发展计划(863计划)(2014AA020516)
国家自然科学基金资助项目(81371807
20873999)