流行性感冒防治药物研究进展

Influenza control drugs:research advances

目前药物防治仍是控制流感的主要措施之一。现有的流感防治药物主要包括M2离子通道阻滞剂和神经氨酸酶抑制剂,临床上虽有一定治疗作用,但其耐药性也日益突显。近年来,随着晶体学、病毒学及其他相关学科在制药领域的深入应用,不少新药已进入临床(前)试验,并取得了良好的抗病毒效果。其中最具代表性的包括广谱抗流感病毒血凝素抗体和病毒RNA聚合酶复合物小分子抑制剂。本文以流感病毒被用于靶标进行药物设计的几种重要蛋白为主线,分别介绍了近年来出现的一些具有较好应用前景的流感防治药物,以期为流感疫情防控提供参考。

Drug control is still one of the main measures to control influenza. The current influenza prevention and treatment drugs mainly include M2 ion channel blockers and neuraminidase inhibitors. They have a certain therapeutic effect,but their resis？tance has also become increasingly prominent. In recent years,with the in-depth application of crystal lography,virology and other re？lated disciplines in the field of pharmacy,many new drugs have entered the（pre-）clinical test stage,and achieved good antiviral ef？fects. The most representatives include broad-spectrum anti-influenza virus hemagglutinin antibody and viral RNA polymerase complex small molecule inhibitors. Here,we introduce some new drugs against influenza so as to provide a reference for the prevention and con？trol of influenza epidemic.