摘要
在中枢神经系统中,神经类固醇激素在胶质细胞内由胆固醇经过一系列酶促反应合成,主要包括脱氢表雄酮、孕烯醇酮、孕酮和四氢孕酮等,通过与γ-氨基丁酸(GABA)受体结合而发挥抗焦虑和抗抑郁样行为学效应,其中神经类固醇激素对机体内环境的稳态具有重要作用。本文就神经类固醇激素的合成、代谢,以及神经类固醇对焦虑症和抑郁症等应激反应的调控作用做一综述,并对相关机制进行探讨。
Neurosteroids are synthesized from cholesterol within the microglia of the central nervous system. They are classi?fied as dehydroepiandrosterone,progesterone,pregnenolone,allopregnanolone and other peripheral steroids. Neurosteroids such as al?lopregnanolone are positive allosteric modulators of GABAA receptors and exert anxiolytic and antidepressant-like behavior. Neuroac?tive steroids play a significant role in neurodevelopment in terms of internal environment homeostasis. This paper reviews the biosynthe?sis,metabolism regulatory effect on the response to stress and therapeutic potentials of neurosteroids.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2017年第3期236-239,共4页
Journal of International Pharmaceutical Research
基金
全军医学科技十二五面上项目(CWS12J084)
关键词
神经类固醇
精神障碍
应激
焦虑
抑郁
neurosteroids
neuropsychiatric disorders
stress
anxiety
depression