血清鳞状细胞癌抗原在各类妇科肿瘤患者中的表达差异

The different levels of squamous cell carcinoma antigen in different kinds of gynecological tumors

目的研究鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)在各类妇科肿瘤患者中的表达差异,以探讨SCC-Ag对诊断宫颈鳞状细胞癌的临床意义。方法选取2009年1月至2014年12月经江西省妇幼保健院确诊的宫颈鳞状细胞癌患者(573例)、宫颈鳞状上皮不典型增生患者(270例)、其他妇科恶性肿瘤患者(305例)及妇科良性肿瘤患者(1459例)为研究对象,检测并比较上述不同类型疾病患者间血清SCC-Ag水平及阳性率。结果宫颈鳞状细胞癌患者血清SCC-Ag水平明显高于宫颈鳞状上皮不典型增生患者、其他妇科恶性肿瘤患者及妇科良性肿瘤患者(P<0.05);宫颈鳞状上皮不典型增生患者血清SCC-Ag水平明显高于妇科良性肿瘤患者(P<0.05),而与其他妇科恶性肿瘤患者比较无显著差异(P>0.05),其他妇科恶性肿瘤与妇科良性肿瘤患者比较无显著差异(P>0.05)。宫颈鳞状细胞癌患者阳性率明显高于宫颈鳞状上皮不典型增生患者(P<0.05),宫颈鳞状上皮不典型增生患者与其他妇科恶性肿瘤患者阳性率比较无显著差异(P>0.05),但二者阳性率均明显高于妇科良性肿瘤患者(P<0.05)。结论血清SCC-Ag水平升高对于诊断宫颈鳞状细胞癌具有一定的参考价值,但需结合其他检查确诊。

Objective To investigate the different levels of serum squamous cell carcinoma antigen （SCC-Ag） in different kinds of gynecological tumors, so as to illuminate its clinical significance for the diagnosus of squamous ell carcinoma of cervix. Method Patients with cervical squamous cell carcinoma （n = 573）, cervical atypical hyperplasia of squamous epithelium （n = 270）, other gynecological cancer （n = 305） and gynecological tumor （n = 1459） were selected in Jiangxi Maternal and Child Health Hospital from January 2009 to December 2014. The levels of SCC-Ag in peripheral blood and the positive rate were examined and compared among those patients. Result The serum SCC-Ag level in cervical squamous cell carcinoma patients was significantly higher than cervical atypical hyperplasia of squamous epithelium patients, other gynecological cancer patients and gynecological tumor patients （P 〈 0.05）, the serum SCC-Ag level in cervical atypical hyperplasia of squamous epithelium patients was significantly higher than that in gynecological tumor patients （P 〈 0.05）, but no significant difference existed compared with other gynecological cancer patients （P 〉 0.05）, it showed no significant difference between other gynecological cancer patients and gynecological tumor patients （P 〉 0.05）. The positive rate of cervical squamous cell carcinoma patients was significantly higher than that of cervical atypical hyperplasia of squamous epithelium patients （P 〈 0.05）, the positive rate of cervical atypical hyperplasia of squamous epithelium patients showed no difference compared with gynecological cancer patients （P 〉 0.05）, both of them were significantly higher than that of gynecological tumor patients （P 〈 0.05）. Conclusion The high level of serum squamous cell carcinoma antigen is helpful to cervical cancer diagnosis, however, other examinations are still needed.