慢性阻塞性肺疾病急性加重期患者中药治疗规律的聚类分析

Cluster analysis of Chinese medicinal formulae in the patients with acute exacerbation of chronic obstructive pulmonary disease

目的使用数据挖掘的方法,对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)中药用药规律进行分析,为临床组方用药提供启发和思路。方法选择211例于2012年1月至2015年12月北京中日友好医院中医肺病科住院的AECOPD患者,其中男性133例,女性78例,年龄最小48岁,最大96岁,平均年龄(74.18±10.46)岁。收集患者中药方剂信息,对数据标准化后进行二次录入。运用系统聚类分析方法对中药应用情况进行分析。结果 188味中药在总共211个方剂中出现,使用频次共计3261次。使用频次在20次以上的共计41味中药,对41味药物使用系统聚类方法进行聚类分析,得出常用药对12对,3味药组合5个,多味药组合2个。结论 AECOPD患者中药应用以清热、涤痰、化湿、宣肺、平喘等药物为主,同时兼与健脾益气、调补肺肾中药并用。

Objective To provide inspiration and ideas for clinical treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） by data mining technology based frequency analysis and cluster analysis of Chinese medicinal formulae （CMF）. Methods Totally 211 medical cases of AECOPD which were hospitalized in China-Japan hospital from January 2012 to December 2015 were collected. The number of male cases was 133, the number of female cases was 78. The max age was 96, the minimum age was 78, the average age was （74.18±10.46）. The information of CMF was input into database twice which trimmed after unified standard. The situation of application of Chinese Herb was performed by the system cluster analysis. Results There were 188 herbs used in 211 CMF, with a total of 3261 times. There were 41 herbs used more than 20 times. The cluster analysis of the 41 herbs showed that 12 pairs of herb pairs were commonly used, and 5 kinds of drug combinations were contained 3 herbs, and 2 kinds of drug combinations were contained multiple herbs. Conclusion The mainly principles of TCM in treatment of AECOPD were clearing heat, removing phlegm, dissipating dampness, dispersing lung, relieving asthma. Besides, at the same time, traditional Chinese medicine with the function of invigorating spleen and supplementing qi and regulating and nourishing the lung and kidney is also used.