前循环脑梗死患者血清PLGF水平与颈动脉粥样斑块超声特征的相关性研究

Correlation between serum Placenta growth factor and the color Dopplor ultrasonography of plaque in carotid arteries of cerebral infarction patients with anterior infarction

目的通过对颈内动脉系脑梗死患者进行颈动脉彩超检查,结合检测胎盘生长因子(PLGF)水平,探寻颈动脉易损斑块的敏感生物学标志物。方法根据颈动脉超声检查情况分为无斑块组、稳定斑块组、不稳定斑块组。对照组为年龄、性别与脑梗死组相匹配的同期住院的非脑血管病患者58例。所有研究对象均采用固相夹心法酶联免疫吸附实验(ELISA)测定血清PLGF,并进行颈动脉超声检查和卒中危险因素的测定,资料中数据均应用SPSS17.0软件进行分析。结果 (1)脑梗死组PLGF水平高于对照组,CAS斑块总检出率及不稳定斑块检出率高于对照组,差异有统计学意义(P<0.05);(2)不稳定斑块组PLGF水平高于稳定斑块组和无斑块组(P<0.05);结论 (1)急性脑梗死患者PLGF水平增高,提示PLGF参与了脑梗死的发生发展过程;(2)急性脑梗死患者不稳定斑块组PLGF水平高于稳定斑块组和无斑块组,提示PLGF水平越高,CAS斑块的稳定性越差,PLGF可作为颈动脉易损斑块的敏感生物学标志物来评估颈动脉病变的严重程度。

Objective To investigate the correlation between the Placenta growth factor（ PLGF） in blood and the color dopplor ultrasonography data of carotidarteries plaque of cerebral infarction（ CI） patients with anterior infarction. Methods All the p Patients were divided into 3 groups： non-plaque group,stable plaque group,unstable plaque group. At the same time 58 patients who without ischemic cerebrovascular disease were selected as control group. All the subjects were examined the levels of serum PLGF and were examined by carotid artery color dopplor ultrasonography. Date in t The datea are were application applied with SPSS17. 0 software for analysis. Results The level of PLGF in the patients of the CI group was significantly higher than those of the control group（ P〈0. 05）. The rates of overall plaques and unstable plaques of the CI group were significantly higher than those of the control group,The levels of serum PLGF in the patients of the unstable plaques group are were significantly higher than those of the non-plaque group and stable plaques group. Conclusion High rate of plaques of carotid artery was found in CI patients,mostly were unstable plaques. The level of PLGF was correlated with the unstable plaques. PLGF can be sensitive of carotid vulnerable plaques biological marker to evaluate the severity of the carotid artery lesions.