黄曲霉毒素对家禽免疫影响的研究进展

Research progress on the effect of aflatoxin on poultry immunization

黄曲霉毒素(AF)是谷物污染的主要污染源之一,是由黄曲霉菌及寄生曲霉菌产生的次生代谢产物,是当前毒性和致癌性最强的物质之一。用黄曲霉毒素污染的粮食饲喂动物会导致中毒、急性肝损伤和肝癌,还可导致多脏器损伤,生产性能下降和抗病能力降低,甚至死亡,给畜牧业带来巨大的经济损失。此外,黄曲霉毒素对人体存在巨大危害,当人体摄入大量黄曲霉毒素,可发生急性中毒,出现急性肝脏损伤;而当微量持续摄入,可造成人体慢性中毒。文章主要从黄曲霉毒素对家禽免疫器官结构功能、免疫基因表达和免疫抑制等几个方面的影响进行论述。

Aflatoxin （AF） is a major pollution source of grain pollution and is secondary metabolite produced by Aspergillus flavus and Aspergillus parasiticus, which is one of the most toxic and carcinogenic substances. Feeding animals with aflatoxin - contaminated food can cause toxicosis, acute liver injury or liver cancer in animals, and also can cause multiple organ damage, decline in production performance and disease resistance, even death, which brings great economic losses to animal husbandry. In addition, AF can do great harm to the human body. When the body ingests large amounts of AF, it can occur in acute poisoning and acute liver damage, while AF can cause chronic poisoning of the body with continuous intake of trace AF. This paper briefly analyzes the effect of AF on the structure and function of poultry immune organs, immune gene expression, immunodepression and so on.