基于4-氨基吖啶酮小分子传感器的设计、合成及识别性能研究

Synthesis and Properties of Small Molecular Sensors for Recognition of Cu^(2+) Based 4-Aminoacridone

基于以往的研究进一步设计合成了一种Cu^(2+)小分子传感器4-((3-甲氧基-4-羟基苄亚基)氨基)吖啶-9(10H)-酮(4-AAVS)。该化合物结构经~1HNMR、^(13)CNMR和HR-MS确认。通过紫外-可见光谱法和荧光光谱法研究4-AAVS在水溶液中对金属离子的识别能力。实验结果表明,在pH 6.24~8.0的水溶液体系中,该化合物对Cu^(2+)表现出优良的选择性识别作用。利用荧光滴定实验可得,该化合物和Cu^(2+)的配位比为2∶1,离子浓度在0.1~0.4×10^(-6)mol/L时,线性相关系数R=0.988 89,最低检出限为1.8×10^(-9)mol/L。

The small molecule 4-（3-methoxyl-4-hydroxylbenzylideneamino） acridin-9（10H）-one（4-AAVS） was synthesized for recognition of Cu^2＋based on our previous studies.The structure of the compound was confirmed by ^1HNMR,^13CNMR and HRMS.The ability to recognize in aqueous solution was evaluated by ultraviolet-visible spectrometry and fluorescence spectroscopy.The results show that the 4-AAVS could selectivity recognition of Cu^2＋in aqueous solution when the value of p H was between6.24 and 8,and fluorescence titration experiment exhibited the complex of 4-AAVS and Cu^2＋was 2∶ 1,fluorescence intensity and the concentration of Cu^2＋show a better linear relationship between 0.1 - 0.4 × 10^-6mol/L,the linear correlation coefficient was 0.988 89,the detection limit was 1.8 × 10^-9mol/L.