1-(溴甲基)-4-环丙基苯的合成研究

Synthesis of 1-(Bromomethyl)-4-cyclopropylbenzene

标题化合物是合成ROR抑制剂、钠-葡萄糖共转运蛋白2抑制剂和5-HT2C兴奋剂的重要中间体。以对溴苯甲醛为起始原料,经Suzuki偶联、还原和溴代反应制得目标产物。本方法成本较低、操作简单且反应条件较为温和,总收率达62.8%。目标化合物的结构经1HNMR和MS确证。

1-（Bromomethyl）-4-cyclopropylbenzene,an important intermediate of ROR-gamma inhibitors,sodium-dependent glucose co-transporter 2 inhibitors and 5-HT2 C agonists,was synthesized by steps of Suzuki coupling reaction,reduction reaction and bromination reaction.The method has the advantages of low cost,simple operation and mild reaction condition,the total product yield was 62.8%.And its structure was confirmed by MS and1 HNMR.