间三氟甲基苯乙酮的合成新方法

Synthesis of 3-Trifluoromethyl-phenylethanone

肟菌酯作为一类重要的甲氧基丙烯酸酯类杀菌剂,市场应用前景广阔。标题化合物是合成肟菌酯的关键中间体,考察了以三氟甲苯与乙酰氯为原料,通过与丁基锂反应,在路易斯酸的催化作用下得到该化合物的方法。通过反应条件优化,实验确定的最佳反应条件是四氢呋喃为格氏反应溶剂,丁基锂用量为0.09 mol,滴加乙酰氯的温度为-10℃,乙酰化反应保温时间为8 h,催化反应的路易斯酸用量为10 mmol氯化亚铜。标题化合物总产率为91%,含量为96%。

Trifloxystrobin is an important strobilurin fungicide with a good impetus and vast potential development.3-Trifluoromethyl-phenylethanone is the key intermediate to synthesize trifloxystrobin.In this work,the intermediate was obtained by taking benzotrifluoride and acetyl chloride as the reactants,butyl lithium as the strong base and catalyzed by Lewis acid.With the optimal reaction conditions,3-trifluoromethyl-phenylethanone was synthesized by taking THF as the Grignard reaction solvent and 0.09 mol amount of butyl lithium.Acetylation was furnished under 10 mmol Cu Cl catalyzed by adding acetylchloride under-10 ℃ and keeping for 8 h.The yield of 3-trifluoromethyl-phenylethanone was reached 91%.The purity of the product was 96%.