青少年肌阵挛癫痫体感诱发电位、事件相关电位P300的特点分析与临床应用

The characteristical and clinical value of Somatosensory Evoked Potential and event-related potential P300 in Patients With Juvenile Myoclonic Epilepsy

目的:通过探讨青少年肌阵挛癫痫(JME)体感诱发电位(SEP)及事件相关电位P300的变化特点,分析其在癫痫患者中的临床应用价值,为JME的发病机制、诊断及监测治疗效果提供神经电生理学依据。方法:选取28例JME(病例组)及30例年龄、性别、文化程度、身高相匹配的健康志愿者(对照组),分别于用药前、药物治疗1年后进行SEP、P300检测。结果:(1)与对照组比较,病例组SEP波幅均明显升高(P=0.000),异常率75%(21/28),SEP潜伏期均无统计学差异(均P>0.05);P300潜伏期明显延长(P=0.000),其中2例P300分化差,9例潜伏期明显延长,异常率39%(11/28),P300波幅差异无统计学意义(P=0.110)。(2)与治疗前比较,治疗后SEP波幅均明显降低(均P<0.05),P300潜伏期明显缩短(P=0.001)。(3)病例组SEP波幅与P300潜伏期之间呈正相关关系(r=0.818,P=0.000)。结论:JME患者SEP皮层各波波幅明显增高,常伴有巨大的SEP,因此SEP可以为JME的发病机制及诊断提供电生理学依据,且对JME患者伴随认知发育异常及临床下病变早发现、早干预。SEP与P300之间存在明显的相关性,动态监测SEP皮层波幅减低及P300潜伏期的缩短情况,可共同作为抗癫痫药物疗效的客观评价指标。

Objective To explore the characteristic and clinical value of Somatosensory Evoked Potential SEP and event- related potential P300 in patients with Juvenile Myoclonic Epilepsy （JME）, trying to provide neuroelectrophysiological evidence for the pathogenesis, diagnosis and antiepileptic drug efficacy of this disease. Methods 28 patients with JME and 30 healthy controls were enrolled in the research. They were applied the SEP and P300 before and after one year treatment. Results （1） The amplitude of SEP in patients with JME was significantly higher than those in the control group（P = 0.000）, the abnormal rate was 75 % （21/28）, while the latency of SEP was no significant difference （P〉0.05）; The latency of P300 in patients with JME was significantly longer （P = 0.000）, 2 out of 28 cases were poorly differentiated, 9 cases were longer （11/28, 39 % ）, while the P300 amplitude was no significant differenee（P = 0.110）. （2） After treatment, the amplitude of SEP was significantly lower （P〈0.05）, the latency of P300 was significantly shorter （P = 0.001）. （3） The amplitude of SEP had a positively linear relationship with the latency of P300 （r = 0.818, P = 0.000）. Conclusions The SEP amplitude was significantly higher in patients with JME, often accompanied by a huge SEP, so SEP can provide electrophysiological evidence for the pathogenesis and diagnosis of this disease.And P300 may give a chance to find the subclinical cognitive abnormalities and to intervent it early. The SEP had a positively linear relationship with the P300, simultaneously dynamic monitoring the change of SEP amplitude and P300 latency may become an objective evaluation for the antiepileptic drug efficacy.