电视胸腔镜与开胸食管癌切除术后并发症与细胞因子的对比研究

The postoperative complications and cytokines in the patients with esophageal carcinoma between VATS and open-thorax operation

目的比较电视胸腔镜与开胸食管癌切除术后并发症与细胞因子含量的情况。方法采用双抗体夹心酶联免疫吸附法(ELISA)测定30例开胸食管癌切除术患者和35例电视胸腔镜联合食管癌切除术患者血清中TNF-α,IL-10,IL-6和IL-12p70的含量,同时比较两种手术方式术后并发症等情况。结果与开胸食管癌切除术相比,电视胸腔镜联合食管癌切除术具有更少的术中出血量和更少的术后住院时间和术后并发症;同时电视胸腔镜联合食管癌切除术患者术后TNF-α,IL-10,IL-6和IL-12p70的含量显著低于开胸食管癌切除术患者。结论电视胸腔镜联合食管癌切除术在术后并发症和术后炎症方面较传统开胸食管癌切除时更具优势。

Objective To compare the postoperative complications and cytokines in the patients of esophageal carcinoma between video assisted thoracic surgery （VATS） and open-thorax operation of esophageal carcinoma. Methods Double antibody sandwich enzyme-linked immunosorbent assay （ELISA） was used to measure the con- centrations of TNF-α, IL-10, IL-6 and IL-12p70 in 35 VATS patients and 30 open-thorax operation of esophageal carcinoma patients, and collected the data of postoperative complications. Results Compared with the open-thorax operation of esophageal carcinoma, the VATS patients had lower blood loss and less postoperative complications; the VATS open-thorax operation patients had lower concentrations of TNF-α, IL-10, IL-6 and L-12p70 than those in of esophageal carcinoma patients. Conclusions VATS has more advantages than that of open-thorax operation of esophageal carcinoma.