摘要
目的观察骨后康颗粒(杜仲、川续断、山萸肉,等)对老年股骨粗隆间骨折患者术后骨代谢指标的影响。方法符合纳入标准的80例患者均行股骨近端防旋髓内钉内固定手术和常规治疗,随机均分为治疗组(骨后康颗粒)和对照组(碳酸钙D_3片),2组疗程均为3个月。术前和术后3个月检测2组患者血清骨钙素(OC)、降钙素(CT)、骨型碱性磷酸酶(BALP)、总Ⅰ型胶原氨基端延长肽(tPINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)及全段甲状旁腺素(iPTH)。结果 2组患者术前血清OC、CT、BALP、tPINP、β-CTX、iPTH水平比较差异无统计学意义,治疗组治疗后OC、CT、BALP、tPINP水平显著上升,β-CTX、iPTH水平显著下降,与术前、对照组术后比较有显著差异。而对照组术前、术后OC、CT、BALP、tPINP、β-CTX、iPTH水平差异无统计学意义。结论骨后康颗粒能有效改善老年股骨粗隆间骨折患者术后的骨代谢,促进骨折愈合。
AIM To observe the effects of Guhoukang Granules (Eucommiae Cortex, Dipsaci Radix, Corni Fructus, etc. ) on bone metabolism indexes of the geriatric femoral intertrochanteric fracture. METHODS A total of eighty patients meeting the inclusion criteria, cured with fixed operation of proximal femoral anti-rotation nail and given basic care, were divided randomly and equally into two groups: experiment group (Guhoukang Granules ) and control group (calcium carbonate D3 tablets). Three months made a course. Osteocalcin (OC), calcitonin (CT), bone-specific alkaline phosphatase (BALP), total procollagen type 1 aminoterminal propeptide (tPINP),β isomer of the C-terminal telopeptide of type I collagen ( β-CTX), and intact parathyroid hormone ( iPTH), were examined before and after three months, respectively. RESULTS There were no significant statistical difference in the levels of OC, CT, BALP, tPINP, β-CTX and iPTH before operation in both groups. The levels of OC, CT, BALP, tPINP in the experiment group obviously increased and the levels of β-CTX, iPTH markedly decreased after the operation, and were better than those in the experiment group pre-operation and in the control group after the operation. The control group had no improvement in bone metabolism indexes pre- and post-opera-tion. CONCLUSION Guhoukang Granules can improve bone metabolism of the geriatric femoral intertrochanteric fracture and facilitate the recovery of the fracture.
出处
《中成药》
CAS
CSCD
北大核心
2017年第4期710-713,共4页
Chinese Traditional Patent Medicine
基金
广东省佛山市科技局医学类攻关项目(2015AB002493)
关键词
骨后康颗粒
老年股骨粗隆间骨折
骨代谢指标
Guhoukang Granules
geriatric femoral intertrochanteric fracture
bone metabolism indexes