骨后康颗粒对老年股骨粗隆间骨折患者术后骨代谢指标的影响

Effects of Guhoukang Granules on bone metabolism indexes of the geriatric femoral intertrochanteric fracture

目的观察骨后康颗粒(杜仲、川续断、山萸肉,等)对老年股骨粗隆间骨折患者术后骨代谢指标的影响。方法符合纳入标准的80例患者均行股骨近端防旋髓内钉内固定手术和常规治疗,随机均分为治疗组(骨后康颗粒)和对照组(碳酸钙D_3片),2组疗程均为3个月。术前和术后3个月检测2组患者血清骨钙素(OC)、降钙素(CT)、骨型碱性磷酸酶(BALP)、总Ⅰ型胶原氨基端延长肽(tPINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)及全段甲状旁腺素(iPTH)。结果 2组患者术前血清OC、CT、BALP、tPINP、β-CTX、iPTH水平比较差异无统计学意义,治疗组治疗后OC、CT、BALP、tPINP水平显著上升,β-CTX、iPTH水平显著下降,与术前、对照组术后比较有显著差异。而对照组术前、术后OC、CT、BALP、tPINP、β-CTX、iPTH水平差异无统计学意义。结论骨后康颗粒能有效改善老年股骨粗隆间骨折患者术后的骨代谢,促进骨折愈合。

AIM To observe the effects of Guhoukang Granules （Eucommiae Cortex, Dipsaci Radix, Corni Fructus, etc. ） on bone metabolism indexes of the geriatric femoral intertrochanteric fracture. METHODS A total of eighty patients meeting the inclusion criteria, cured with fixed operation of proximal femoral anti-rotation nail and given basic care, were divided randomly and equally into two groups： experiment group （Guhoukang Granules ） and control group （calcium carbonate D3 tablets）. Three months made a course. Osteocalcin （OC）, calcitonin （CT）, bone-specific alkaline phosphatase （BALP）, total procollagen type 1 aminoterminal propeptide （tPINP）,β isomer of the C-terminal telopeptide of type I collagen （ β-CTX）, and intact parathyroid hormone （ iPTH）, were examined before and after three months, respectively. RESULTS There were no significant statistical difference in the levels of OC, CT, BALP, tPINP, β-CTX and iPTH before operation in both groups. The levels of OC, CT, BALP, tPINP in the experiment group obviously increased and the levels of β-CTX, iPTH markedly decreased after the operation, and were better than those in the experiment group pre-operation and in the control group after the operation. The control group had no improvement in bone metabolism indexes pre- and post-opera-tion. CONCLUSION Guhoukang Granules can improve bone metabolism of the geriatric femoral intertrochanteric fracture and facilitate the recovery of the fracture.