胃铋镁四联疗法治疗柯尔克孜族慢性胃炎的效果

Effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgiz patients with chronic gastritis

目的观察胃铋镁四联疗法对柯尔克孜族慢性胃炎患者治疗的效果。方法选择2015年12月~2016年11月克孜勒苏柯尔克孜自治州人民医院收治的柯尔克孜族Hp相关慢性胃炎患者160例,随机分为治疗组和对照组,每组80例。治疗组口服胃铋镁颗粒+奥美拉唑+阿莫西林+克拉霉素14 d,对照组口服胶体果胶铋+奥美拉唑+阿莫西林+克拉霉素14 d,两组患者再增加服用铋剂14 d。比较Hp根除、上腹痛缓解及不良反应发生情况。结果治疗组Hp根除率为91.2%,略优于对照组的81.2%,差异无统计学意义(P>0.05)。治疗组上腹痛症状缓解率为100.0%,显著优于对照组的92.5%,差异有统计学意义(P<0.05)。治疗组不良反应发生率为5.0%,显著低于对照组的18.8%,差异有统计学意义(P<0.01)。结论胃铋镁四联疗法在临床上对柯尔克孜族慢性胃炎患者Hp根除效果显著,对上腹痛症状缓解效果优于胶体果胶铋四联疗法,同时减少了不良反应发生,值得在少数民族地区推广。

Objective To observe the clinical effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgi.z patients with chronic gastritis.Methods 160 cases of Kirgiz patients with chronic gastritis admitted to the People＇s Hospital of Kzilsu Kirgiz Autonomous Prefecture from December 2015 to November 2016 were chosen and randomly divided into treatment group and control group,with 80 cases in each group.The patients in the treatment group was given compound Bismuth and Magnesium Granules＋Omeprazole＋Amoxicillin＋Clarithromycin for 14 days;the patients in the control group was given Colloidal Bismuth Peetin＋Omeprazole＋Amoxicillin＋ Clarithromycin for 14 days;and the patients were added the Bismuth preparation for another 14 days in both groups.Hp eradication,gastrointestinal symptoms improvement and adverse drug reaction were compared between 2 groups.Results The rate of Hp eradication in the treatment group was 91.2%,which was slightly higher than that in the control group for 81.2%,and there was no statistieant difference （P〉0.05）.The upper abdominal pain symptoms improvement rate was 100.0% in the treatment group,which was higher than that in the control group for 92.5%,with statisticant difference（P〈 0.05）.The ADR rate in the treatment group was 5.0%,lower than that in the control group for 18.8%,with statisticant dif- ference （P〈0.01）.Conclusion Compound bismuth and magnesium granules-containing quadruple therapy in the clinical treatment on Kirgiz chronic gastritis has a significant effect,it＇s remission of upper abdominal pain symptoms has better effects than colloidal bismuth pectin-containing quadruple therapy,what＇s more,it decrease the ADR rate.So,it is worthy of clinical promotion between minority areas.