青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G、白细胞介素-17、超敏C反应蛋白水平变化的意义

The relationship between the serum ACA-IgG,IL-17 and hsCRP concentration and middle cerebral artery atherosclerotic stenosis of young adults

目的探讨青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G(ACA-IgG)、白细胞介素-17(IL-17)及超敏C反应蛋白(hsCRP)水平与大脑中动脉狭窄程度的关系。方法对78例缺血性脑卒中患者行数字减影全脑血管造影(DSA),根据DSA结果将患者分为无狭窄组(21例)、轻度狭窄组(22例)、中度狭窄组(18例)和重度狭窄组(17例),检测比较各组血清ACA-IgG、IL-17、hsCRP水平。结果无狭窄组及轻、中、重度狭窄组血清ACA-IgG水平分别为(25.53±6.23)k U/L、(36.14±6.67)k U/L、(47.75±8.31)k U/L、(62.41±11.26)k U/L,血清IL-17水平分别为(35.54±11.32)ng/L、(57.62±19.06)ng/L、(64.05±28.67)ng/L、(78.36±25.01)ng/L,血清hsCRP水平分别为(2.06±1.53)mg/L、(4.23±1.17)mg/L、(5.30±1.34)mg/L、(6.72±2.01)mg/L;大脑中动脉轻、中、重度狭窄组血清ACA-IgG、IL-17水平显著增高(F=15.36,10.16,9.58;P<0.05);Logistic回归分析显示,血清ACA-IgG及IL-17水平增高预测颅内动脉狭窄的比值比(OR)为1.624和1.235。结论 ACA-IgG、IL-17在青中年大脑中动脉粥样硬化性狭窄的发生和发展过程中可能起重要作用。

Objective To explore the relationship between the serum anticardiolipin antibodyimmune globulin G （ ACA-IgG）, interleukin-17 （IL-17） and high-sensitivity C-reactive protein （ hsCRP ） concentration and intracerebral artery stenosis middle cerebral artery atherosclerotic stenosis. Methods By digital subtraction angiography （DSA）,78 patients with ischemic cerebrovaseular disease were enrolled and divided into a stenosis-free group （ 21 cases）, mild-stenosis group （ n = 22）, moderate-stenosis group （ n = 18） ,and severe-stenosis group （ n = 17）.The level of serum ACA-IgG,IL-17 and hsCRP were detected. Results The levels of serum ACA-IgG in the stenosis-free group, mild, moderate and severe stenosis groups were （ 25.53±6.23 ） kU/L, （ 36.14±6.67 ） kU/L, （ 47.75 ± 8.31 ） kU/L and （ 62.41 ± 11.26 ） kU/L respectively. The levels of serum IL- 17 were （ 35.54± 11.32） ng/L, （57.62± 19.06） ng/L, （64.05±28.67） ng/L and （ 78.36± 25.01 ） ng/L respectively.The level of serum hsCRP were （ 2.06± 1.53 ） mg/L, （ 4.23± 1.17 ） mg/L, （ 5.30± 1.34） mg/L and （ 6.72 ± 2.01 ） mg/L respectively. Compared with stenosis-free group, the levels of serum ACA-IgG and IL-17 were significantly increased in the mild, moderate and severe stenosis groups（ all P 〈 0.05）.Logistic regression analysis showed that the odds ratio （OR） of hyper ACA-IgG and IL-17 for intracerebral artery stenosis were 1.624 and 1.235, respectively. Conclusion ACA-IgG and IL-17 may play an important role in middle cerebral artery atherosclerotic stenosis of young adult.