肝纤维化无创性诊断方法的研究进展

Research advances of non-invasive diagnosis of liver fibrosis

肝纤维化是慢性肝病向终末期肝病进展的必经阶段,早期诊断并及时干预可以逆转,因此,肝纤维化的早期诊断备受关注。尽管目前肝纤维化诊断的金标准仍然为病理学诊断,但无创检查已逐渐成为临床发展的方向,主要包括血清肝纤维化标志物、影像学及其最新的分子生物学基因检测技术等无创诊断方法。为了临床合理选择肝纤维化诊断的方法,现将各种无创诊断方法的现状综述如下。

Liver fibrosis is an inevitable process of chronic liver diseases with different causes which may lead to end-stage liver diseases.If liver fibrosis patients are diagnosed and intervented timely, then the liver fibrosis can be reversed.In recent years, the non-invasive diagnosis of liver fibrosis gets widely attention, mainly including serologic markers, imaging diagnosis, genetics and so on. In order to select the appropriate live fibrosis diagnostic methods, the various non-invasive diagnostic methods of live fibrosis are summarized as follows.