奥美拉唑联合莫沙必利治疗胃食道管反流病的临床疗效观察

Clinical Observation of Omeprazole Combined with Mosapride in Treating Reflux Esophagitis

目的探讨临床中奥美拉唑联合莫沙必利治疗胃食道管反流病(RE)的临床疗效,并对该方法治疗胃食管反流病的有效程度加以说明。方法随机选取我院自2015年1月至2016年3月期间收治的胃食道管反流病(RE)患者100例,对所有患者采用随机抽取的方法随机分为实验组和对照组,每组50例;实验组患者采用奥美拉唑联合莫沙必利进行临床治疗,奥美拉唑40 mg/d,每天2次,口服;莫沙必利15 mg/d,每天3次,口服。治疗时间为60 d。对照组患者仅用奥美拉唑进行治疗剂量为40 mg/d,每天2次,口服;治疗时间为60 d。治疗时间结束后对比分析两组的治疗效果,对两组的总有效率进行对比分析。结果通过对两组数据的分析实验组的总有效率为92%,对照组的总有效率为68%,实验组与对照组的临床疗效数据比较有统计学意义(P<0.05)。结论奥美拉唑联合莫沙必利治疗胃食道管反流病(RE)的效果明显,疗效显著,值得在临床治疗中进行推广应用。

Objective Investigate omeprazole combined with mosapride in treatment of reflux esophagitis （RE） clinical efficacy, the effectiveness of the methods of treatment of gastroesophageal reflux disease to illustrate this. Method Random selected hospital since January 2015 to March 2016 during admitted of stomach esophagus tube anti-flow disease patients 100 cases, on all patients used random extraction of method random is divided into experiment group and control group, each group 50 cases; experiment group patients used omeprazole combined with mosapride for clinical treatment, omeprazole 40 nag/d, daily 2 times, oral; mosapride 15 mg/d, daily 3 times, oral. Control group patients were treated with omeprazole dose of 40 mg/d, 2 times daily. Treatment of comparative analysis of therapeutic effect in both groups at the end of time. Result Through the analysis of two sets of data total effective rate in the experimental group was 92%, total effective rate of 68% in the control group, the experimental group and the control group with a statistically significant clinical efficacy data （P〈0.05）. Conclusion Omeprazole combined with mosapride in treating reflux disease gastroesophageal tube.