高分辨率磁共振评价阿托伐他汀钙对颈动脉硬化不稳定斑块的影响

Effect of atorvastatin calcium therapy for unstable carotid plaque evaluated by high resolution nuclear magnetic resonance imaging

目的利用高分辨率磁共振评估不同剂量阿托伐他汀钙对人颈动脉硬化不稳定斑块的影响。方法选择有颈动脉不稳定斑块患者100例,随机分成高剂量组和低剂量组,分别给予20mg和10mg阿托伐他汀钙,于治疗前和治疗1a后行高分辨率磁共振检查,结合患者的血脂和超敏C反应蛋白水平,对不稳定斑块的数量和平均厚度进行分析。结果治疗1a后,患者血脂中的总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均有所降低,高密度脂蛋白胆固醇水平升高;经高分辨磁共振检查,动脉硬化不稳定斑块的数量及平均厚度与治疗前相比明显降低(P<0.05)。结论阿托伐他汀钙能够使患者的血脂、超敏C反应蛋白降低,具有抗动脉粥样硬化的作用。

Objective To evaluate the effects of 20 mg or 10 mg atorvastatin on the unstable carotid atherosclerosis plaque by high resolution nuclear magnetic resonance imaging（MRI）. Methods Totally 100 inpatient cases with unstable carotid plaque from March 2013 to May 2016 were randomly divided into high-dose group and low-dose group,which received 20 mg and 10 mg atorvastatin respectively. High resolution nuclear MRI before and one year after treatment was applied and levels of plasma lipids and C-reactive protein were detected to assess the quantity and average thickness of unstable plaque. Results One year after treat ment, blood lipid levels such as total cholesterol, triglycerides and low-density lipoprotein eholesterin were decreased and high-den sity lipoprotein cholesterol level was increased. High resolution nuclear MRI showed that the quantity and average thickness of un stable plaque were dramatically reduced compared with those before treatment（P〈0.05）. Conclusion Atorvastatin calcium can decrease the blood lipid and C-reactive protein levels and has an effect on anti-atherosclerosis.