自拟防复汤治疗小儿反复呼吸道感染临床研究

Clinical Study of Self-defined Relapse-prevention Decoction in the Treatment of Children with Recurrent Respiratory Tract Infection

目的:观察自拟防复汤对反复呼吸道感染患儿外周血Th17细胞的影响,从而评估其临床疗效。方法:将符合条件的113例反复呼吸道感染患儿随机分为2组,对照组根据所患疾病及咽拭子培养结果、血清学检验结果选用适当的药物抗感染或抗病毒及对症处理,治疗组在对照组基础上予自拟防复汤,2组均以1个月为1个疗程,连续治疗3个疗程。观察2组患儿外周血Th17细胞的变化及治疗有效率。结果:治疗组患儿的外周血Th17细胞较治疗前明显下降,对照组下降的幅度小于治疗组(P<0.05);治疗组有效率85.96%,对照组62.50%,2组比较,差异有显著意义(P<0.01)。结论:自拟防复汤能有效降低外周血的Th17细胞,提高患儿的临床疗效。

Objective： To observe the effect of self-defined relapse-prevention decoction on Th17cells in the peripheral blood of children with Recurrent Respiratory Tract Infection （ RRTI）, and to evaluate its clinical curative effect. Methods ：113cases with RRTI in children were randomly divided into 2groups. According to their diseases and results of throat swab cul- tures, serological test, the control group were cured by the appropriate antimicrobia or antiviral drugs and symptomatic treat- ment. While the treatment group were based on those treatments with self-defined relapse-prevention decoction. Both of them were given I month as one treatment period, 3courses intotal. The changes of Thl7cells and the effectiveness rate of treatment were observed in 2groups. Results： The expression rate of Thl7cells in the treatment group were significantly lower than that be- fore treatment, while the control one decreased less than it （P〈0. 05 ） ; The effective rate of treatment group was 85.96%, con- trol group 62. 50%. 2groups had significant difference （P〈0. 01 ）. Conclusion ： The self-defined relapse-prevention Decoction can effectively reduce the the expression rate of Thl7cells, and improve the clinical efficacy in children.