沈阳市部分离退休干部人群血尿酸水平与高血压病关系的调查研究

Investigation of the Relationship between the Level of Serum Uric Acid and Hypertension among the Retired Cadres in Shenyang

目的:探讨沈阳市部分离退休干部人群血尿酸水平与高血压病的关系。方法:以2012年8月至2013年8月在沈阳医学院附属中心医院干诊部定点体检的346名离退休干部为研究对象,统一进行问卷调查并收集年龄、性别等基本指标及收缩压、舒张压、空腹血糖等临床指标,分析不同性别及不同血尿酸水平研究对象的高血压病的患病情况。结果:调查人群的高血压病患病比例为50.00%(173/346),其中男性为51.01%(152/298),女性为43.75%(21/48);男性高尿酸组的高血压病患病比例显著高于血尿酸正常组(P<0.05)。根据血尿酸水平对男性人群进行四分位分组比较,发现4组(血尿酸水平P_(75)以上)收缩压值显著高于1组(血尿酸水平P_(25)以下),高血压病患病比例显著高于1组与3组(血尿酸水平P_(50)-P_(75)),差异均有统计学意义(P<0.05);通过对男性人群血尿酸水平与高血压病进行二元Logistic回归分析,发现4组高血压病发病风险为1组的4.975倍。结论:血尿酸水平的增高与老年人群,尤其是男性人群高血压病的患病关系密切,积极监测老年人群血尿酸水平并及时开展高尿酸血症的相应治疗,对于预防高血压病的发生发展具有重要意义。

Objective： To investigate the relationship between the level of serum uric acid and hypertension among the retired cadres in Shenyang. Methods： A total of 346 retired cadres who had physical examinations in the Central Hospital Affiliated to Shenyang Medical College from Aug 2012 to Aug 2013 were regarded as the research objects. A unified questionnaire survey was done and the age, gender, systolic blood pressure, diastolic blood pressure, fasting blood glucose and other basic and clinical indicators were collected. Results： The prevalence of hypertension was 50% in all investigators, 50.01% in males and 43.75% in females. The prevalence of hypertension in the high uric acid group was significantly higher than that in the normal group in males （P〈0.05） .Since the males were categorized into quartiles according to the levels of the uric acid, systolic blood pressure in group 4 （serum uric acid〉PTs） was significantly higher than that in group 1 （serum uric acid〈P25）, also the prevalence of the hypertension was higher than that in group 1 and group 3 （P50 serum uric acid≤P75）. The difference was statistically significant （P〈0.05）. Logistic regression analysis showed that the risk of hypertension in group 4 was 4.975 times that in group 1. Conclusions ： There is significant relationship between the level of serum uric acid and hypertension among the elderly cadres in Shenyang, especially among the males. Population with higher level of serum uric acid have higher risk of hypertension. It is important to actively monitor the level of serum uric acid in the elderly population and improve the corresponding treatment of hyperuricemia.