早期应用小剂量多巴胺联合呋塞米治疗心功能Ⅲ～Ⅳ级心力衰竭的有效性分析

Analysis on the Effectiveness of Early Application of Small Dose of Dopamine Combined with Furosemide in the Treatment of Heart Failure Patients with Ⅲ～Ⅳ Degree Cardiac Function

目的研究早期应用小剂量多巴胺与呋塞米联合治疗心功能Ⅲ~Ⅳ级心力衰竭的临床效果。方法选取2014年3月至2016年8月我院收治的112例心功能Ⅲ~Ⅳ级心力衰竭患者,随机分为研究组与对照组各56例。研究组在早期给予小剂量多巴胺与呋塞米联合进行治疗,对照组单纯给予呋塞米进行治疗,比较两组的治疗效果。结果研究组的总有效率为94.64%,显著高于对照组的75.00%(P<0.05)。研究组的住院时间显著短于对照组,利尿剂抵抗和肾功能恶化的发生率显著低于对照组,B型脑钠肽(BNP)水平显著低于对照组,差异均有统计学意义(P<0.05)。结论在心功能Ⅲ~Ⅳ级心力衰竭患者的临床治疗中,早期给予小剂量多巴胺与呋塞米联合治疗能够获得显著的临床疗效,且安全性高。

Objective To study the clinical effect of early application of small dose of dopamine combined with furosemide in the treatment of heart failure patients with Ⅲ-Ⅳ degree cardiac function. Methods 112 cases of heart failure patients with Ⅲ-Ⅳ degree cardiac function admitted to our hospital from March 2014 to August 2016 were selected and randomly divided into two groups,with 56 cases in each group. The study group received early application of small dose of dopamine combined with furosemide,while the control group was treated with furosemide only. The curative effects of two groups were compared. Results The total effective rate of study group was 94.64%,significantly higher than 75.00% of control group,with statistical difference（P〈0.05）. The length of hospital stay of study group was significantly shorter than that of control group,the incidence of diuretic resistance and incidence of deterioration of renal function were significantly lower than those of control group,and the level of B-type natriuretic peptide（BNP） was significantly lower than that of control group,with statistical differences（P〈0.05）. Conclusions Early application of small dose of dopamine combined with furosemide in the treatment of heart failure patients with Ⅲ-Ⅳ degree cardiac function has significant clinical efficacy and high safety.