阿奇霉素联合米诺环素、甲强龙治疗小儿难治性肺炎支原体肺炎的临床效果

Clinical Effect of Azithromycin Combined with Minocycline and Methylprednisolone in the Treatment of Pediatric RMPP

目的研究阿奇霉素联合米诺环素、甲强龙治疗小儿难治性肺炎支原体肺炎(RMPP)的临床效果。方法选取90例RMPP患儿,随机均分为两组。实验组使用阿奇霉素联合米诺环素和甲强龙治疗,对照组仅使用阿奇霉素治疗。结果实验组的症状、体征消失时间和住院时间均显著短于对照组(P<0.05)。治疗后,两组的炎性指标水平均显著降低(P<0.05),且实验组各指标水平均显著低于对照组(P<0.05)。治疗后,实验组的肺部阴影面积显著小于对照组,阴影基本吸收率显著高于对照组(均P<0.05)。两组的不良反应发生率无统计学差异(P>0.05);实验组的复发率为2.22%,显著低于对照组的11.11%(P<0.05)。结论阿奇霉素联合米诺环素、甲强龙治疗小儿RMPP具有显著的临床效果。

Objective To study the clinical effect of azithromycin combined with minocycline and methylprednisolone in the treatment of children with refractory mycoplasma pneumoniae pneumonia（RMPP）. Methods 90 cases of children with RMPP were selected and randomly divided into two groups equally. The experimental group was treated with azithromycin combined with minocycline and methylprednisolone,while the control group was treated with azithromycin only. Results The disappeared time of symptoms and signs,and hospitalization time of experimental group were significantly shorter than those of control group（P〈0.05）. After treatment,both groups had significantly decreased levels of inflammatory indicators（P〈0.05）,and the experimental group was significantly lower than the control group in the levels of inflammatory indicators（P〈0.05）. After treatment,the pulmonary shadow area of experimental group was significantly less than that of control group,and the rate of shadow absorption was significantly higher than that of control group（both P〈0.05）. No statistical difference was found between two groups in the incidence of adverse reactions（P〉0.05）,while the recurrence rate of experimental group was significantly lower than that of control group（2.22% vs. 11.11%,P〈0.05）. Conclusions Azithromycin combined with minocycline and methylprednisolone in the treatment of pediatric RMPP has significant clinical effect.