乌司他丁联合地塞米松对肝癌切除术后肝功能的保护作用研究

Study on the Protective Effect of Ulinastatin Combined with Dexamethasone on the Hepatic Function After Resection of Liver Cancer

目的研究乌司他丁联合地塞米松对常温下阻断第一肝门血流行肝癌切除术患者肝功能的保护作用。方法选择60例常温下行第一肝门血流阻断肝癌切除术的患者,分为研究组和对照组各30例,其中研究组患者予乌司他丁联合地塞米松由门静脉注入,比较两组的肝功能。结果研究组的吲哚氰绿15分钟滞留率(RICG15)低于对照组,口服葡萄糖耐量试验(OGTT)正常者多于对照组,血清前白蛋白数值(PA)高于对照组,肝功能衰竭发生率低于对照组,组间比较差异均有统计学意义(P<0.05)。结论乌司他丁联合地塞米松经门静脉注入,对肝癌切除术后患者的肝功能有明显的保护作用。

Objective To study the protective effect of ulinastatin combined with dexamethasone on the hepatic function of patients after resection of liver cancer with normothermic first hepatic portal intermittent ischemia. Methods 60 cases of patients with normothermic first hepatic portal intermittent ischemia in the resection of liver cancer were selected and divided into two groups equally. The study group received ulinastatin combined with dexamethasone through portal vein injection,while the control group didn＇t. The hepatic function was compared between two groups. Results The retention rate of indocyanine green at 15 min（ICGR15） of study group was significantly lower than that of control group,the proportion of normal oral glucose tolerance test（OGTT） result was significantly higher than that of control group,the level of serum prealbumin（PA） was significantly higher than that of control group,and the incidence of hepatic failure was significantly lower than that of control group; All the differences between the study group and the control group were statistically significant（all P〈0.05）. Conclusions Ulinastatin combined with dexamethasone through portal vein injection has significant protective effect on postoperative hepatic function of patients with resection of liver cancer.