两种静脉途径在直肠癌患者FolFox4化疗方案中的应用

The application of patients with rectal carcinoma underwent the FolFox4 chemotherapy protocol by two intravenous route

目的探讨两种静脉途径在直肠癌患者FolFox4化疗方案中的应用效果。方法分析陕西省榆林市第二医院2014年5月~2016年6月收治的170例直肠癌手术患者临床资料,依据静脉途径不同进行分组,治疗Ⅰ组(PICC置管)80例和治疗Ⅱ组(浅静脉留置针)90例。观察两组直肠癌患者静脉损伤、临床效果、生活质量改善、静脉输液疼痛评分情况。结果治疗Ⅰ组直肠癌患者静脉损伤程度分级优于治疗Ⅱ组(P<0.05),治疗Ⅰ组直肠癌患者临床治疗总缓解率和生活质量改善情况高于治疗Ⅱ组(P<0.05),治疗Ⅰ组直肠癌患者静脉输液疼痛评分低于治疗Ⅱ组(P<0.05)。结论在直肠癌患者中应用PICC置管联合便携式化疗泵,可以明显降低患者静脉损伤程度,提高患者临床疗效和生活质量,降低静脉输液疼痛,值得临床推广应用。

Objective To approach the application of patients with rectal carcinoma underwent the FolFox4 chemotherapy protocol by two intravenous route. Methods 170 patients with rectal carcinoma in the Second Hospital of Yulin City from May 2014 to June 2016 were selected and divided into two groups by vein approach, with 80 cases in treatmentⅠgroup（PICC cannulation） and 90 cases in treatmentⅡgroup（superficial vein catheter）. The venous injury, clinical effect, life quality improvement, intravenous infusion pain score of two groups were compared. Results The vein injury grade of treatment I group was better than that of treatmentⅡgroup（P 〈 0.05）. The total remission rate of clinical treatment and life quality improvement of treatmentⅠgroup were higher than that of treatmentⅡgroup（P 〈 0.05）. The intravenous infusion pain score of treatmentⅠgroup was lower than that of treatmentⅡgroup（P 〈 0.05）. Conclusion The application of PICC cannulation compared with portable chemotherapy pump in patients with rectal carcinoma,which can decrease vein injury grade, increase clinical effect and life quality, and decrease venous transfusion pain. It is worthy of clinical application.