血浆氨基末端脑钠肽前体水平在冠心病患者抑郁障碍早期预测中的价值

The early predictive value of the plasma level of N-terminal pro-brain natriuretic peptide level in patients with coronary heart disease

目的探讨冠心病患者血浆中氨基末端脑钠肽前体(NT-pro BNP)水平与抑郁障碍的关系。方法选取2015年10月至2016年5月华北理工大学附属唐山工人医院的冠心病患者142例,根据汉密尔顿抑郁量表(HAMD)评分将冠心病患者分为抑郁组与非抑郁组,并测定血浆NT-pro BNP水平。结果冠心病患者抑郁检出率为33.8%;抑郁组与非抑郁组年龄、体重指数、在职情况、血浆NT-pro BNP水平比较差异均有统计学意义(均P<0.05);两组间性别、婚姻状况、疾病类型、发病次数、心功能Killip分级,糖尿病、高血压、高血脂症、脑血管病检出率,心脏手术史及他汀类药物、阿司匹林使用率比较差异均无统计学意义(均P>0.05);多因素Logistic回归分析结果显示,血浆NT-pro BNP水平、体重指数与冠心病患者的抑郁障碍有关(P<0.05)。结论血浆NT-pro BNP水平是冠心病患者抑郁障碍的独立危险因素,有助于冠心病患者发生抑郁障碍的早期预测。

Objective To investigate the relationship between the level of N-terminal pro-brain natriuretic peptide（ NT-pro BNP） in plasma of patients with coronary heart disease（ CHD） and depression.Methods 142 CHD patients were divided into non-depressive and depressive groups according to the Hamilton Depression Scale（ HAMD） score. The plasma NT-pro BNP level was measured.Results The detection rate of depression in patients with CHD was 33. 8%. There were statistically significant differences on age,body mass index,the working state,the plasma NT-pro BNP levels between depressive and non-depressive groups（ P〈0.05）. There were no statistically significant differences on gender,marital status,type of disease,frequency of onset,heart function Killip class,detection rate of diabetes,hypertension,high blood fat disease,cerebrovascular disease,history of cardiac surgery and statin drug,aspirin administration（ P〉0.05）. The plasma level of NT-pro BNP and body weight index were associated with depression in patients with CHD（ P〈0.05）.Conclusions The plasma level of NT-pro BNP is an independent risk factor for depression in patients with CHD,which is helpful for the early prediction of depression in CHD patients.