抗肿瘤类靶向制剂靶向性评价方法研究进展

Research progress in targeting evaluation methods for anti-tumor targeted drug delivery system

与传统制剂相比,靶向制剂可以提高药物选择性、降低不良反应、增强疗效、提高患者顺应性等,成为新药研发的热点。建立科学合理的靶向性评价技术与方法,对保证该类药物制剂的安全、有效、质量可控具有重要作用。本文对抗肿瘤类靶向制剂的靶向机制以及注册和上市情况进行了概述,并重点介绍了靶向性评价技术与方法,为抗肿瘤类靶向制剂的质量研究和控制提供参考。

Targeted drug delivery system has become a hot topic in research and development of new drugs. Compared to traditional preparations,targeted drug delivery system may increase drug selectivity and reduce adverse reactions,enhance efficacy,improve patient compliance,and so on. The establishment of scientific and reasonable targeting evaluating technology and methods plays an important role in guaranting the safety and efficacy as well as a controllable quality. In this review,we briefly introduced the targeting mechanism,and registered and marketed anti-tumor targeted drug products. In particular,the targeting evaluating technologies and methods were featured in this review. These will provide some strategies for quality research and control methods of anti-tumor targeted drug delivery system.