摘要
TH1/TH2失衡是儿童性哮喘发病的主要机制,T-bet和GATA-3分别作为促Th1细胞分化和促TH2细胞分化的关键转录因子,其比值(T-bet/GATA-3)可以用来衡量Th1/Th2平衡。由远端细支气管上的非纤毛上皮细胞Clara细胞分泌的CC16,具有抗炎、抗氧化、抗纤维化、免疫调节等生物学活性,与儿童性哮喘的发生发展密切相关。那么,CC16是否是通过作用于T-bet/GATA-3而恢复Th1/Th2平衡,从而缓解儿童性哮喘?本文就儿童性哮喘、CC16、T-bet/GATA-3失衡三者之间的联系作一综述.
The imbalance of Th1/Th2 is the main pathogenesis of asthma in children. T-bet and GATA-3 are the master regulatory transcription factors of Th 1 and Th2 respectively, and their ratio （T-bet/GATA-3） can be regarded as the indicator of Th1/Th2. Clara cell secretory protein（CC16）, secreted by Clara ceils which are nonciliated epithelial cells and cover in terminal bronchioles, has anti-inflammatory, anti-oxidative, anti-fibrotic and immunomodulatory properties, and has a close relationship with pathogenesis and progression of asthma in children. Therefore, does CC16 restore Th1/Th2 balance and relieve asthma by acting on T-bet/GATA-3？ The purpose of this review is to analyze the relation of asthma in children, CC 16 and imbalance of T-bet/GATA-3.
出处
《解剖科学进展》
2017年第2期204-207,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81302405)
