Nrf2的代谢调节作用与肿瘤的生长和增殖

The Function of Nrf2 in Metabolic Regulation and Its Role in Tumor Growth and Proliferation

核转录因子Nrf2[nuclear factor erythroid 2(NFE2)related factor 2]是细胞内重要的调节因子。通过与Keap1(Kelch-like-ECH associated protein 1)蛋白质的相互作用,Nrf2可以调控下游基因转录,发挥抗氧化应激、维持细胞内稳态的功能,而Nrf2在肿瘤细胞中的表达与肿瘤的发生发展具有重要关系。Nrf2通过调节肿瘤细胞代谢模式调控细胞生长和增殖,近年来成为了细胞生物学和肿瘤生物学领域的研究热点之一。该文介绍了Nrf2对于活性氧分子产生与清除以及多种物质代谢途径的调控作用,着重阐明Nrf2的代谢调节作用对肿瘤细胞生长增殖的影响及其与肿瘤耐药的关系,旨在为今后的临床研究提供更多信息。

The Nrf2 [nuclear factor erythroid 2（NFE2） related factor 2], whose activity is regulated by Keap1（Kelch-like-ECH associated protein 1） through proteasomal degradation, plays a cytoprotective role in the cell by facilitating downstream gene transcription for defending against oxidative stress and maintaining cellular redox homeostasis. Besides, the existence of Nrf2 in cells is of great significance in tumor metabolism and growth, which becomes one of the current research focuses in cell and cancer biology. In this paper, we reviewed the effects of Nrf2 on the generation and scavenging of ROS（reactive oxygen species） and cellular metabolism. In addition, we also focused on how Nrf2 affects tumor growth and proliferation through metabolic regulation, and introduced its relationship to tumor drug resistance in order to cast insight on further clinical research.