喹诺酮类-铜(Ⅱ)-芳胺混配配合物的研究进展

Recent Progress on Research in Mixed-Ligand Copper (Ⅱ) Complexes Containing Quinolones and Aromatic Amines

含喹诺酮类及芳胺的铜(Ⅱ)配合物具有重要的应用价值,可作化学核酸酶、SOD模拟物及抗菌剂等,因而得到了快速发展,成为生物无机化学的重要研究内容之一。本文结合本课题组研究工作,综述了国内外对喹诺酮类-铜(Ⅱ)-芳胺混配配合物的结构、化学核酸酶活性、SOD模拟及其抗菌作用的研究进展。同时提出了今后研究工作的方向。

The copper（Ⅱ） complexes with quinolones and aromatic amines has been flourishing and become an important research field of bioinorganic chemistry, since the complexes can be used as chemical nucleases, SOD mimics and antibacterial agents, etc. Based on the studies of authors＇ laboratory, the research progress on the structure, chemical nuclease activity, SOD simulation and antibacterial action of this kind of copper（Ⅱ） complexes is reviewed. Moreover, with these described above as basis, some related suggestions are given.