代谢相关性肌细胞因子的研究进展

A research progress on metabolism-associated myokines

肌细胞因子(myokines)是由肌细胞合成和释放,发挥自分泌、旁分泌或内分泌功能的细胞因子及多肽类物质。肌细胞因子可作用于骨骼肌自身及脂肪、肝脏、胰腺、骨骼等多种组织器官参与机体物质和能量代谢并影响各组织器官的结构和功能,从而在维持机体的生物学稳态中发挥重要作用。目前已发现的肌细胞因子有数百种,其中鸢尾素(irisin)、肌联素(myonectin)、肌肉抑制素(myostatin)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)等对机体糖脂及能量代谢起到重要作用。本文主要阐述上述几种代谢相关性肌细胞因子的合成和分泌、生理作用、作用机制及潜在临床应用。

Cytokines and peptides produced and released by muscle cells and exert either autocrine, paracrine or endocrine effects are defined as myokines. Myokines are capable of exerting specific endocrine effects on organs such as adipose tissue, liver, pancreas and bone, thereby impacting the structure and function of numerous organs and tissues, as well as playing an important role in the maintenance of biological homeostasis. So far, researches have confirmed hundreds of different myokines, including irisin, myonectin, myostatin and brain-derived neurotrophic factor （BDNF）, which can affect glucose and lipid metabolism, as well as energy equilibrium. The generation, physiology, mechanism of action and potential clinical value of these metabolism-associated myokines will be reviewed in this article.