摘要
目的探讨上皮性卵巢癌(EOC)患者外周血血小板(PLT)计数、纤维蛋白降解产物(FDP)及D-二聚体(DD)的变化与临床价值。方法选择2012年10月至2016年6月安徽医科大学第一附属医院妇产科就诊的108例EOC患者作为观察组,依据临床病理分期分为早期组(FIGOⅠ期和Ⅱ期,33例)和晚期组(FIGOⅢ期和Ⅳ期,75例),另选取同期手术治疗的卵巢良性肿瘤患者20例作为对照组,所有患者均于治疗前检测外周静脉血PLT计数、FDP和DD,并进行比较分析。结果观察组患者的PLT计数、FDP和DD分别为(271.49±97.21)×109/L、(15.05±14.78)mg/L和(5.21±5.31)mg/L,均高于对照组,差异有统计学意义(P<0.05);晚期组患者的PLT计数、FDP和DD分别为(291.92±103.54)×109/L、(19.05±15.53)mg/L和(6.65±5.62)mg/L,均高于早期组,差异有统计学意义(P<0.05)。结论 EOC患者外周血的PLT计数、FDP和DD水平高于卵巢良性肿瘤患者,且临床病理分期越高,升高水平也越显著,值得临床重视。
Objective To explore the changes of PLT,FDP and DD levels and its clinical significance in patients with epithelial o-varian cancerrisk（EOC）. Methods A total of 108 EOC patients of the First Affiliated Hospital of Anhui Medical University from Oct 2012 to Jun 2016 were taken as observation group, and another 20 cases of benign ovarian tumor were selected as control group, and then the cases in observation groupwere divided into into two subgroups according to the clinical pathological stage, the early stage group （FIGO Stage I and II ） with 33 cases, and late stage group （FIGO Stage Hand IV） with 75 cases, all patients were measured in terms of PLT, FDP and DD val-ues of peripheral venous blood before treatment,and then the differences among groupswere analyzed. Results The levels of PLT, FDP and DD values in observation group were （271. 49 ± 97. 21） x 109/L,（ 15. 05 ± 14. 78 ） mg/L and （5. 21 ±5. 31） mg/L, respectively, higher than those in control group （ P 〈 0. 05 ）. The levels in late stage group were （291.92 ±103.54） × 109/ L , （ 19. 05 ± 1 5 .5 3 ） mg/L and （6 .6 5 ± 5. 62）mg/L, respectively, higher than those in early stage group, and the difference were statistically significant（P 〈0. 05）. Conclusion The levels of PLT, FDP and DD levels in EOC patientsare higher than those in patients with benign ovarian tumor, and the increased levelis more significant with higher clinical pathological stage, which calls for duly attention in clinic.
出处
《安徽医学》
2017年第3期288-290,共3页
Anhui Medical Journal
