心脉隆注射液对糖尿病合并慢性心力衰竭老年病人的疗效观察

Clinical Observation on Xinmailong Injection in the Treatment of Elderly Diabetic Patients with Chronic Heart Failure

目的观察心脉隆注射液对糖尿病合并慢性心力衰竭(CHF)老年病人的疗效。方法糖尿病合并慢性心力衰竭老年病人78例,随机分为两组。对照组39例进行常规治疗;心脉隆注射液治疗组39例,心脉隆注射液6 mL加入5%葡萄糖200 mL或生理盐水200 mL中静脉滴注,08:00和16:00各一次。两组均以5 d为1个疗程,观察两个疗程。观察两组治疗后的临床效果,比较左室射血分数(LVEF)和血浆脑钠肽(BNP)水平的变化,记录不良反应发生情况。结果治疗后,对照组显效13例,有效18例,无效8例;治疗组显效21例,有效15例,无效3例,两组治疗效果间差异有统计学意义(P<0.05)。治疗后治疗组LVEF高于对照组,BNP水平低于对照组,差异均有统计学意义(P<0.05)。两组均未见严重不良反应发生。结论心脉隆注射液可降低糖尿病合并CHF老年病人的心脏负荷,改善心功能。

Objective To observe the clinical efficacy of Xinmailong injection（XMLI）in the treatment of elderly diabetic patients with chronic heart failure（CHF）.Methods Seventy-eight elderly diabetic patients with CHF were randomly divided into two groups：control group（n =39）treated with routine treatment,and treatment group（n =39）treated with routine treatment and XMLI for 10 days.The clinical effect of the two groups after treatment were observed.The changes of left ventricular ejection fraction（LVEF）and plasma brain natriuretic peptide（BNP）levels after treatment were compared between the two groups.The adverse reactions were observed.Results After treatment,the clinical efficacy in treatment group was better than that in control group（P 〈0.05）.LVEF in treatment group was significantly higher in treatment group than that in control group while BNP level was significantly lower in treatment group than that in control group（P 〈0.05）.There was no serious adverse reactions occurred in two groups.Conclusion XMLI can decrease cardiac load and improve heart function in elderly diabetic patients with CHF.