胰岛素抵抗程度与高血压患者血压的相关性分析

Relationship between Insulin Resistance and Hypertension

目的探讨胰岛素抵抗(IR)程度与高血压患者血压的相关性。方法选取2011年10月—2013年2月重庆市万州区人民医院住院的高血压患者90例为高血压组,根据高血压分级标准,分为1级高血压组30例、2级高血压组30例、3级高血压组30例,另选取同时期血压正常者90例为对照组。分别测定空腹血糖(FPG)、空腹胰岛素(FINS),并计算稳态模型评估的胰岛素抵抗指数(HOMA-IR)。结果高血压组与对照组性别、年龄、吸烟、饮酒、身高、体质量比较,差异均无统计学意义(P>0.05)。高血压组FPG、FINS及HOMA-IR较对照组升高(P<0.05)。不同高血压分级组患者FPG、FINS及HOMA-IR比较,差异均有统计学意义(P<0.05);其中2级高血压组和3级高血压组患者FPG、FINS及HOMA-IR较1级高血压组升高(P<0.05);3级高血压组患者FPG、FINS及HOMA-IR较2级高血压组升高(P<0.05)。结论 IR与高血压相关,血压越高,HOMA-IR越高。

Objective To study the relationship between insulin resistance（ IR） and hypertension. Methods Ninety hospitalized hypertension patients in Chongqing Wanzhou District People’s Hospital from October 2011 to February 2013 as hypertension group,were divided into grade 1 hypertension group（ n = 30）,grade 2 hypertension group（ n = 30）,and grade 3hypertension group（ n = 30） by hypertension grading standaed. In the same period of normal blood pressure of 90 patients were selected as control group. FPG, FINS were tested, and HOMA-IR was counted. Results The differences were not statistically significant in gender,age,smoking,drinking, height, body mass between hypertension group and control group（ P 〉 0. 05）. FPG,FINS,HOMA-IR in hypertension group were higher than those in control group（ P 〈 0. 05）. The differences were statistically significant in FPG,FINS,HOMA-IR among difference hypertension grading group（ P 〈 0. 05）.FPG,FINS,HOMA-IR in grade 2 hypertension group and grade 3 hypertension were higher than those in grade 1 hypertension group（ P 〈 0. 05）. FPG,FINS,HOMA-IR in grade 3 hypertension were higher than those in grade 2 hypertension group（ P〈 0. 05）. Conclusion IR is associated with hypertension,the higher the level of blood pressure,the higher the HOMA-IR.