胸腔镜下射频消融治疗低肺功能非小细胞肺癌患者临床疗效研究

Effect of Therapy of Radiofrequency Ablation on Non-small Cell Lung Cancer Patient with Low Pulmonary Function

目的分析胸腔镜下射频消融术治疗低肺功能非小细胞肺癌患者的临床效果。方法选取2014年1月—2016年1月柳州市中医院治疗的低肺功能非小细胞肺癌患者60例为研究对象,根据不同的治疗方法将患者分为观察组和对照组,各30例。观察组患者采取胸腔镜下射频消融术,并同期行纵隔淋巴结清扫治疗,对照组患者采取单纯吉西他滨+顺铂治疗,评价两组临床疗效。结果观察组总有效率为90.0%(27/30),高于对照组的70.0%(21/30)(P<0.05)。观察组患者1年生存率为86.4%,2年生存率为59.1%,中位生存时间为26个月;对照组1年生存率为50.0%,2年生存率为26.9%,中位生存时间为11个月。观察组中位生存时间长于对照组(P<0.05)。结论胸腔镜下射频消融术治疗低肺功能非小细胞肺癌患者短期疗效明确,安全性高,远期效果尚需进一步证实。

Objective To evaluate the clinical effect of thoracoscopic radiofrequency ablation in the treatment on non-small cell lung cancer patients with low pulmonary function. Methods 60 patients with low pulmonary function and non-small cell lung cancer treated in Liuzhou Hospital of TCM from January 2014 to January 2016 were selected as study subjects. According to treatment methods,the patients were divided into observation group and control group,and 30 cases of each group. Patients in the observation group underwent thoracoscopic radiofrequency ablation, and mediastinal lymph node dissection were conducted. The patients in the control group were treated with gemcitabine and cisplatin. The clinical effectiveness were evaluated. Results The total effective rate in the observation group was 90. 0%（ 27/30）,which was higher than that in the control group（ 70. 0%,21/30）（ P 〈 0. 05）. The 1-year survival rate was 86. 4%,the 2-year survival rate was 59. 1%,and the median survival time was 26 months in the observation group. The 1-year survival rate was 50. 0%,the2-year survival rate was 26. 9%,and the median survival time was 11 months in the control group. The median survival time of the observation group was longer than that of the control group（ P 〈 0. 05）. Conclusion Non-small cell lung cancer patients with low pulmonary function,treated by radiofrequency ablation,have a clear short-term efficacy and safety. While long-term efficacy need to be further confirmed.